Publication

Proof of Concept of a Novel Optical Glucose Enzyme-Based Micro-Biosensor using SU-8

Nico de Rooij
2011
Conference Papers

Abstract

A novel one-step microfabrication process of SU-8 films for the development of inexpensive light-weight and small size optical glucose micro-biosensors is proposed. Experimental work was carried out in order to investigate whether SU-8 photoresists, which are polymers widely used in MEMS applications, can be utilised as immobilisation matrices for the simultaneous encapsulation of glucose oxidase and an oxygen-sensitive fluorescent indicator. The immobilisation of the enzyme, the encapsulation of the indicator and the patterning of the custom-made SU-8 take place simultaneously, thus simplifying the microfabrication process.

Official source

https://infoscience.epfl.ch/entities/publication/79558f8a-6ff6-4f0f-8612-d696af63aff2

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Nico de Rooij
2011
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/79558f8a-6ff6-4f0f-8612-d696af63aff2

About this result

Related concepts (32)

Microfabrication

Microfabrication is the process of fabricating miniature structures of micrometre scales and smaller. Historically, the earliest microfabrication processes were used for integrated circuit fabrication, also known as "semiconductor manufacturing" or "semiconductor device fabrication". In the last two decades microelectromechanical systems (MEMS), microsystems (European usage), micromachines (Japanese terminology) and their subfields, microfluidics/lab-on-a-chip, optical MEMS (also called MOEMS), RF MEMS, PowerMEMS, BioMEMS and their extension into nanoscale (for example NEMS, for nano electro mechanical systems) have re-used, adapted or extended microfabrication methods.

Biosensor

A biosensor is an analytical device, used for the detection of a chemical substance, that combines a biological component with a physicochemical detector. The sensitive biological element, e.g. tissue, microorganisms, organelles, cell receptors, enzymes, antibodies, nucleic acids, etc., is a biologically derived material or biomimetic component that interacts with, binds with, or recognizes the analyte under study. The biologically sensitive elements can also be created by biological engineering.

Enzyme

Enzymes (ˈɛnzaɪmz) are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps.

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Proof of Concept of a Novel Optical Glucose Enzyme-Based Micro-Biosensor using SU-8

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