Publication

Metabolic and functional changes in retinitis pigmentosa: comparing retinal vessel oximetry to full-field electroretinography, electrooculogram and multifocal electroretinography

2016
Journal Articles

Abstract

PurposeTo determine a relationship between the retinal vessel saturation alterations and the residual retinal function measured by means of full-field electroretinography (full-field ERG), electrooculogram (EOG) and multifocal electroretinography (mfERG) in patients with retinitis pigmentosa (RP). MethodsRetinal vessel oximetry (RO), full-field ERG, EOG and mfERG were performed on 43 eyes of 22 patients suffering from RP and were compared to those of 26 eyes of 13 healthy controls. The oxygen saturation in the first and second branch retinal arterioles (A-SO2) and venules (V-SO2) was measured, and their difference (A-V SO2) was calculated. Full-field ERG amplitudes, EOG parameters and averaged mfERG response amplitudes (within central 3 degrees, between 3 degrees and 8 degrees, 8 degrees and 15 degrees, 15 degrees and 24 degrees) were evaluated in relation to the RO measurements. ResultsV-SO2 correlated negatively with the full-field ERG and EOG values, with increasing functional damage the V-SO2 was higher. The RP group was well distinguished from the controls when the RO measurements were correlated to the averaged N1 (baseline to trough), but also to the N1P1 (trough-to-peak) mfERG response amplitudes. Receiver operating characteristic (ROC) curve of V-SO2, compared to those of N1 and N1P1 mfERG response averages (15-24 degrees), presented a high differential margin between RP and controls (p

Official source

https://infoscience.epfl.ch/entities/publication/7858eea8-8fc3-47bc-8a26-2dda321ccbef

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2016
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/7858eea8-8fc3-47bc-8a26-2dda321ccbef

About this result

Related concepts (32)

Electroretinography

Electroretinography measures the electrical responses of various cell types in the retina, including the photoreceptors (rods and cones), inner retinal cells (bipolar and amacrine cells), and the ganglion cells. Electrodes are placed on the surface of the cornea (DTL silver/nylon fiber string or ERG jet) or on the skin beneath the eye (sensor strips) to measure retinal responses. Retinal pigment epithelium (RPE) responses are measured with an EOG test with skin-contact electrodes placed near the canthi.

Retina

The retina (from rete "net"; : retinae or retinas) is the innermost, light-sensitive layer of tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which then processes that image within the retina and sends nerve impulses along the optic nerve to the visual cortex to create visual perception. The retina serves a function which is in many ways analogous to that of the film or in a camera.

Retinitis pigmentosa

Retinitis pigmentosa (RP) is a genetic disorder of the eyes that causes loss of vision. Symptoms include trouble seeing at night and decreasing peripheral vision (side and upper or lower visual field). As peripheral vision worsens, people may experience "tunnel vision". Complete blindness is uncommon. Onset of symptoms is generally gradual and often begins in childhood. Retinitis pigmentosa is generally inherited from one or both parents. It is caused by genetic variants in nearly 100 genes.

Related publications (18)

Metabolic and functional changes in retinitis pigmentosa: comparing retinal vessel oximetry to full-field electroretinography, electrooculogram and multifocal electroretinography

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