Publication

Method for detecting non-racemic mixtures using cold ion photofragmentation mass spectrometry

Oleg Boyarkine
2025

Abstract

The present invention relates to an optical spectroscopic method for determining in absence of enantiopure standards of a target molecule whether a mixture of enantiomers of said molecule in a test composition is non-racemic. the method relies upon the combination of cold ion spectroscopy and mass spectroscopy detection. the method includes formation of diastereoisomers of the target molecule with each of the l- and d- enantiomers of a chiral reporter molecule and comparison of the photofragmentation spectra recorded for said diastereoisomers.

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https://infoscience.epfl.ch/entities/publication/74a622df-151b-48f1-b5ff-4bd24d3d43f6

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Oleg Boyarkine
2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/74a622df-151b-48f1-b5ff-4bd24d3d43f6

About this result

Related concepts (31)

Spectroscopy

Spectroscopy is the field of study that measures and interprets the electromagnetic spectra that result from the interaction between electromagnetic radiation and matter as a function of the wavelength or frequency of the radiation. Matter waves and acoustic waves can also be considered forms of radiative energy, and recently gravitational waves have been associated with a spectral signature in the context of the Laser Interferometer Gravitational-Wave Observatory (LIGO).

Enantiomer

In chemistry, an enantiomer (/ɪˈnænti.əmər, ɛ-, -oʊ-/ ih-NAN-tee-ə-mər; from Ancient Greek ἐνάντιος (enántios) 'opposite', and μέρος (méros) 'part') – also called optical isomer, antipode, or optical antipode – is one of two stereoisomers that are non-superposable onto their own . Enantiomers are much like one's right and left hands, when looking at the same face, they cannot be superposed onto each other. No amount of reorientation in three spatial dimensions will allow the four unique groups on the chiral carbon (see chirality) to line up exactly.

Enantiopure drug

An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. Chirality can be observed when the geometric properties of an object is not superimposable with its mirror image. Two forms of a molecule are formed (both mirror images) from a chiral carbon, these two forms are called enantiomers.

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Method for detecting non-racemic mixtures using cold ion photofragmentation mass spectrometry

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