A three-dimensional self-opening intraneural peripheral interface (SELINE)

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Recent advances in the development of intra-cortical neural interfacing devices show the bright horizon of having access to brain-implantable microsystems with extremely high channel counts in the not-so-distant future. With the fabrication of high-density ...

The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimen ...

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to ...

Bending-active elastica beam is a structural configuration that is based on the elastic deformation of an initially straight beam. This deformation occurs when horizontal displacements are applied to a sliding support, causing the beam to bend into an arch ...

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

Animals, including humans, exhibit a remarkable variety of complex behaviours. How the nervous system controls all these behaviours ranging from simple, stereotyped movements to flexible, adaptive actions is a central questions of neuroscience. One of the ...

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

Several boreholes were drilled for site comparison of a deep geological repository (DGR) in Northern Switzerland. The main target of the exploration program was the >100m thick Opalinus Clay, the designated host rock encountered at approximately 450 to 100 ...

In recent years, there has been a surge of interest in predicting computed activation barriers, to enable the acceleration of the automated exploration of reaction networks. Consequently, various predictive approaches have emerged, ranging from graph-based ...

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

The brain is an ultra-soft viscoelastic matrix. Sub-kPa hydrogels match the brain's mechanical properties but are challenging to manipulate in an implantable format. We propose a simple fabrication and processing sequence, consisting of de-hydration, patte ...

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether and how sensory cells in the central nervous system (CNS) become activated during bacteri ...

Kirigami, the ancient technique of paper cutting, has been successfully applied to enhance the stretchability and ductility of nanoscale graphene. However, existing experimentally realized graphene kirigami (GK) are created by introducing parallel cuts, ex ...

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...

The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hypothesize that ...

Three-dimensional topological semimetals have emerged as strong candidates to probe new fundamental physical phenomena that could be exploited to develop next generation electronics. However, many aspects of their electronic properties remain unclear. Thi ...

A three-dimensional self-opening intraneural peripheral interface (SELINE)

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Real-time, Neural Signal Processing for High-density Brain-implantable Devices

Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System

Short-term behavior of glass fiber-polymer composite bending-active elastica beam under service load application

A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Uncovering interactions between Descending Neurons as a functional principle of behavioural control

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Insights from an extensive triaxial testing campaign on a shale for comparative site characterization of a deep geological repository

Benchmarking machine-readable vectors of chemical reactions on computed activation barriers

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

Deformation response of highly stretchable and ductile graphene kirigami under uniaxial and biaxial tension

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Strain Gradients and Magnetoresistance in Microstructured 3D Topological Semi-metals