SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

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Pioneer transcription factors (TFs) engage chromatinized DNA motifs. However, it is unclear how the resultant TF-nucleosome complexes are decoded by co-factors. In humans, the TF p53 regulates cell-cycle progression, apoptosis, and the DNA damage response, ...

The growing global obesity issue emphasizes the importance of understanding its health implications. Previous research has identified consistent alterations in gray matter (GM) volume in connection with obesity. Given the various implications of distinct f ...

Adipose tissues serve as an energy reservoir and endocrine organ, yet the mechanisms that coordinate these functions remain elusive. Here, we show that the transcriptional coregulators, YAP and TAZ, uncouple fat mass from leptin levels and regulate adipocy ...

The aluminium sector relies on natural gas for the conversion of recycled scrap into new feedstock, which results in substantial atmospheric emissions. Hydric resources are also impacted, as they serve as heat sinks for the waste heat generated during the ...

In this work, a tool to design district heating networks (DHN) is presented and applied to the city of Lausanne as a case study. The evaluation of the buildings’ heat/cooling demand is performed using a Geographic Information System (GIS) database, built f ...

Molecular quantum dynamics simulations are essential for understanding many fundamental phenomena in physics and chemistry. They often require solving the time-dependent Schrödinger equation for molecular nuclei, which is challenging even for medium-sized ...

Recently, single-particle cryo-electron microscopy emerged as a technique capable of determining protein structures at near-atomic resolution and resolving protein dynamics with a temporal resolution ranging from second to milliseconds. This thesis describ ...

Frontal polymerisation has the potential to bring unprecedented reductions in energy demand and process time to produce fibre reinforced polymer composites. Production of epoxy-based fibre reinforced polymer parts with high fibre volume content, commonly e ...

The transition towards clean renewable energy sources, where wind and solar are prone to variation, requires adequate energy storage. Power-to-methane (PtM) systems can be part of the solution. Specifically, solid-oxide-electrolyser (SOE) based PtM systems ...

The vast amount of computational studies on electrical conduction in solid-state electrolytes is not mirrored by comparable efforts addressing thermal conduction, which has been scarcely investigated despite its relevance to thermal management and (over)he ...

The heat flux mitigation during the thermal quench (TQ) by the shattered pellet injection (SPI) is one of the major elements of disruption mitigation strategy for ITER. It's efficiency greatly depends on the SPI and the target plasma parameters, and is ult ...

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

Regulation of gene expression is a complex but highly guided process. While genomic technologies and computational approaches have allowed high-throughput mapping of cis-regulatory elements (CREs) and their interactions in 3D, their precise role in regulat ...

Heating, Ventilation, and Air Conditioning (HVAC) Systems utilize much energy, accounting for 40% of total building energy use. The temperatures in buildings are commonly held within narrow limits, leading to higher energy use. Measurements from office bui ...

Annealing furnaces are critical for achieving the desired material properties in the production of high-quality aluminum products. In addition, energy efficiency has become more and more important in industrial processes due to increasing decarbonization r ...

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated como ...

Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...

Energy efficiency is crucial for the sustainable operation of all industrial and urban sectors. However, practicing engineers have seldom access to open-source tools that can readily evaluate and compare scenarios in terms of energy consumption, cost, and ...

The process synthesis and optimization methods used in this work include simulation of biomass gasification, hydrogen and synthetic natural gas production, and jet fuel production via a Fisher Tropsch unit. An energy integration approach, carried out by th ...

The latest European polices highlight the urgent need to rehabilitate the existing building stock, responsible for 40 % of the EU's total energy consumption. In this process, a key role is played by thermal simulations, assessing the effective energy perfo ...

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

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Nucleosomes specify co-factor access to p53

The interplay between white adipose tissue, adipokines, and structural gray matter changes

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Renewable energy integration and waste heat valorization in aluminum remelting for co-producing kerosene and methanol

Decomposition method to evaluate district heating/cooling network potential at urban scale

High-order geometric integrators for the variational Gaussian wavepacket dynamics and application to vibronic spectra at finite temperature

Microsecond Time-Resolved Cryo-Electron Microscopy

Self-catalysed frontal polymerisation enables fast and low-energy processing of fibre reinforced polymer composites

Design and assessment of an evaporating water-cooled methanation reactor for a SOE-based power-to-methane system

Thermal conductivity of Li 3 PS 4 solid electrolytes with ab initio accuracy

Plasmoid drift and first wall heat deposition during ITER H-mode dual-SPIs in JOREK simulations

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Chromatin modules and their implication in genomic organization and gene regulation

DIET Controller: Dynamic Indoor Environment using Deep Reinforcement Learning

Improved Waste Heat Management and Energy Integration in an Aluminum Annealing Continuous Furnace Using a Machine Learning Approach

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

ROSMOSE: A Web-based Optimization Tool to Aid Decision-making for the Design and Operation of Industrial and Urban Energy Systems

Renewable Energy Integration and Waste Heat Recovery for the Production of Sustainable Jet Fuel and Decarbonization of Industrial Heating Applications

A modelling framework for modern heritage buildings energy simulation