Publication

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Maroun Bou Sleiman, Xiaoxu Li
2023
Journal Articles

Abstract

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial role for it in maintaining brown adipocyte mitochondrial OXPHOS and thermogenesis upon cold stimulus.

Official source

https://infoscience.epfl.ch/entities/publication/0773a73e-95f6-4976-a7e5-c36e22e1bd11

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Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

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