Mechanisms of differential centriole inheritance in C. elegans

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Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the ...

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Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the centromere to spindle microtubules d ...

In most metazoans, centrioles are lost during oogenesis, ensuring that the zygote is endowed with the correct number of two centrioles, which are paternally contributed. How centriole architecture is dismantled during oogenesis is not understood. Here, we ...

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Mechanisms of differential centriole inheritance in C. elegans

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Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos

Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination

Extensive programmed centriole elimination unveiled in C. elegans embryos

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Towards understanding centriole elimination

Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

The nuclear-to-cytoplasmic ratio drives cellularization in the close animal relative Sphaeroforma arctica

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