Her9 controls the stemness properties of hindbrain boundary cells

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Spindle positioning and spindle elongation are critical for proper cell division. In human cells, an evolutionary conserved ternary complex (NuMA/LGN/Gαi) anchors dynein at the cortex during metaphase, thus ensuring correct spindle positioning. Whether thi ...

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Patients with MCPH (autosomal recessive primary microcephaly) exhibit impaired brain development, presumably due to the compromised function of neuronal progenitors. Seven MCPH loci have been identified, including one that encodes centrosome protein 4.1 as ...

Stem cells are characterized by their dual ability to reproduce themselves (self-renew) and specialize (differentiate), yielding essentially unlimited numbers of daughter cells that can maintain and regenerate tissues. In contrast to their embryonic counte ...

Heterotrimeric G-proteins are integral to a conserved regulatory module that influences metazoan asymmetric cell division (ACD). In the Caenorhabditis elegans zygote, GOA-1 (Galpha(o)) and GPA-16 (Galpha(i)) are involved in generating forces that pull on a ...

The present invention provides methods for inducing differentiation of a stem cell, such as an embryonic stem cell, into a hematopoietic stem cell, by expressing a cdx gene and/or a hox gene. The method is useful for generating expanded populations of hema ...

Her9 controls the stemness properties of hindbrain boundary cells

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Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Capturing Cardiogenesis in Gastruloids

Delta-Notch signalling in segmentation

Mechanical and Functional Study of Cell Physiology at the Nanoscale

A balancing act between stratification and EMT in cultured human thymic epithelial cells

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

Activation and Spatial Organization of the Adenosine A2A Receptor in Supported Plasma Membrane Sheets

Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL

Artificial stem cell niches

Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans

Method of enhancing proliferation and/or hematopoietic differentiation of stem cells