Publication

Real-time chemical reaction monitoring with 25 MHz low-field NMR

2026

Abstract

Real-time reaction monitoring with Nuclear Magnetic Resonance (NMR) spectroscopy is an emerging and increasingly important analytical technique. In this work, we develop and implement software to identify molecules and monitor a chemical reaction in real time using a low-field benchtop NMR operating at 24.35 MHz. The approach was validated using a simple acid-catalyzed elimination reaction, the dehydration of cyclohexanol to cyclohexene, and enabled both qualitative and semi-quantitative assessment of the reaction progress. Automated peak integration and yield calculation were performed at each time step, and the results were benchmarked against a high-field 400 MHz Bruker NMR instrument.

Official source

https://infoscience.epfl.ch/entities/publication/69ae4fd2-6144-4966-8e23-0f37d45163ef

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2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/69ae4fd2-6144-4966-8e23-0f37d45163ef

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Related concepts (32)

Chemical reaction

A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaking of chemical bonds between atoms, with no change to the nuclei (no change to the elements present), and can often be described by a chemical equation. Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive elements where both electronic and nuclear changes can occur.

Nuclear magnetic resonance

Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca.

Nuclear magnetic resonance spectroscopy

Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique to observe local magnetic fields around atomic nuclei. This spectroscopy is based on the measurement of absorption of electromagnetic radiations in the radio frequency region from roughly 4 to 900 MHz. Absorption of radio waves in the presence of magnetic field is accompanied by a special type of nuclear transition, and for this reason, such type of spectroscopy is known as Nuclear Magnetic Resonance Spectroscopy.

Related publications (32)

Real-time chemical reaction monitoring with 25 MHz low-field NMR

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