Publication

Finite element modelling of the bone-implant interface and experimental validation

2015
Student Projects

Abstract

Excessive interfacial micromotion endangers the implant primary stability by favoring the formation of a fibrous tissue layer at the bone-implant interface. It was recently proposed that implant micromotion induces fluid flow in the granulation tissue that forms between the implant and bone right after implantation. This fluid flow might in turn affect the differentiation of the mesenchymal stromal cells (MSCs) hosted in this tissue. Therefore, there is a high interest in characterizing the micromotion-induced fluid flow at the bone-implant interface. In this project, a FE model of the bone-implant interface will be used to study the influence of implant micromotion, implant geometry and material definition on fluid flow in the granulation tissue.

Official source

https://infoscience.epfl.ch/entities/publication/6c760bdd-b2a5-4915-b588-a91cc60848b6

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2015
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/6c760bdd-b2a5-4915-b588-a91cc60848b6

About this result

Related concepts (32)

Dental implant

A dental implant (also known as an endosseous implant or fixture) is a prosthesis that interfaces with the bone of the jaw or skull to support a dental prosthesis such as a crown, bridge, denture, or facial prosthesis or to act as an orthodontic anchor. The basis for modern dental implants is a biological process called osseointegration, in which materials such as titanium or zirconia form an intimate bond to the bone. The implant fixture is first placed so that it is likely to osseointegrate, then a dental prosthetic is added.

Connective tissue

Connective tissue is one of the four primary types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesenchyme, derived from the mesoderm, the middle embryonic germ layer. Connective tissue is found in between other tissues everywhere in the body, including the nervous system. The three meninges, membranes that envelop the brain and spinal cord, are composed of connective tissue. Most types of connective tissue consists of three main components: elastic and collagen fibers, ground substance, and cells.

Tissue engineering

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds.

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Finite element modelling of the bone-implant interface and experimental validation

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