Publication

Mechanical properties of individual microtubules measured using atomic force microscopy

László Forró, Giovanni Dietler, Andras Kis, Andrzej Kulik
2000
Conference Papers

Abstract

Atomic force microscopy has been used to investigate the mechanical properties of microtubules. Method of Salvetat et al. [1], originally developed for measuring the Young's modulus of carbon nanotubes, has been extended to a biological system of similar geometry. Preliminary measurements of Young's modulus of microtubules in this configuration give a value of 74 MPa. Compression measurements on the same system give a value of 22 MPa, which is of the same order of magnitude, while values previously reported in the literature have a dispersion of 3 orders in magnitude, from 1MPa to 1GPa. Further improvements of our method will enable comparison between the properties of different types of microtubules, for example, between those from healthy and diseased tissue.

Official source

https://infoscience.epfl.ch/entities/publication/666da11f-c4ea-4b07-90de-1fd2c5c76ce9

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László Forró, Giovanni Dietler, Andras Kis, Andrzej Kulik
2000
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/666da11f-c4ea-4b07-90de-1fd2c5c76ce9

About this result

Related concepts (32)

Microtubule

Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm and have an inner diameter between 11 and 15 nm. They are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin into protofilaments that can then associate laterally to form a hollow tube, the microtubule. The most common form of a microtubule consists of 13 protofilaments in the tubular arrangement.

Apparent magnitude

Apparent magnitude (m) is a measure of the brightness of a star or other astronomical object. An object's apparent magnitude depends on its intrinsic luminosity, its distance, and any extinction of the object's light caused by interstellar dust along the line of sight to the observer. The word magnitude in astronomy, unless stated otherwise, usually refers to a celestial object's apparent magnitude. The magnitude scale dates back to the ancient Roman astronomer Claudius Ptolemy, whose star catalog listed stars from 1st magnitude (brightest) to 6th magnitude (dimmest).

Physical property

A physical property is any property that is measurable, involved in the state of a physical system, whose value represents the intensity on the object's state and behavior. The changes in the physical properties of a system can be used to describe its changes between momentary states. A quantifiable physical property is called physical quantity. Measurable physical quantities are often referred to as observables. Physical properties are often characterized as intensive and extensive properties.

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Mechanical properties of individual microtubules measured using atomic force microscopy

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