Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

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Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...

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The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

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Activin-A is a Transforming Growth Factor-B (TGFB)-related cytokine that regulates various biological processes including cell proliferation and differentiation through autocrine, paracrine or endocrine signaling. Activin-A expression is upregulated in mul ...

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Glutathione (GSH) is the main determinant of intracellular redox potential and participates in multiple cellular signalling pathways. Achieving a detailed understanding of intracellular GSH homeostasis depends on the development of tools to map GSH compart ...

Dreissena polymorpha is a bivalve promising for biomonitoring in freshwater ecosystems thanks to its abundance and high filtration activity allowing rapid uptake of toxicants and identification of their negative effects. Nonetheless, we still lack knowledg ...

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The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

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Understanding hormone signaling and its risk on estrogen receptor-positive breast cancer

Engineering hydrogel microenvironments for epithelial organoid culture

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Computational drug development for membrane protein targets

Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC

Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

Towards Uncovering the Mechanisms of Electrophile Sensing and Signaling

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

A locally activatable sensor for robust quantification of organellar glutathione

Bioaccumulation and molecular effects of carbamazepine and methylmercury co-exposure in males of Dreissena polymorpha

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

Tumor dormancy: EMT beyond invasion and metastasis

Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy