Publications related to Capturing complex 3D tissue physiology in vitro

3D diffractive optics for linear interconnects and nonlinear processing

The optical domain presents potential avenues for enhancing both computing and communication due to its inherent properties of bandwidth, parallelism, and energy efficiency. This research focuses on harnessing 3-Dimensional (3D) diffractive optics for nove ...

EPFL2024

Deep Learning for 3D Surface Modelling and Reconstruction

Benoît Alain René Guillard

In recent years, there has been a significant revolution in the field of deep learning, which has demonstrated its effectiveness in automatically capturing intricate patterns from large datasets. However, the majority of these successes in Computer Vision ...

EPFL2023

Volumetric additive manufacturing in a scattering resin

Jorge Andres Madrid Wolff

Volumetric 3D printing is a novel technique that offers promising new perspectives in tissue engineering. In volumetric 3D printing, photosensitive gels or liquids are solidified by projecting light patterns via reverse tomography. Recent results show that ...

EPFL2023

Automated post-earthquake damage assessment of stone masonry buildings integrating machine learning, computer vision, and physics-based modeling

Bryan German Pantoja Rosero

Current post-earthquake damage assessment methodologies are not only time-consuming but also subjective in nature and difficult to document. Recent advancements in artificial intelligence and technological devices make it possible to accomplish this task a ...

EPFL2023

ISP: Multi-Layered Garment Draping with Implicit Sewing Patterns

Pascal Fua, Benoît Alain René Guillard, Ren Li

Many approaches to draping individual garments on human body models are realistic, fast, and yield outputs that are differentiable with respect to the body shape on which they are draped. However, they are either unable to handle multi-layered clothing, wh ...

2023

Studies on EU-DEMO 3D coils requirements and conceptual design for error field correction and plasma control

Pierluigi Bruzzone, Hartmut Zohm, Leonardo Pigatto

This work presents the initial studies on the requirements for the design of 3D coils on EU-DEMO. The use of 3D coils in present machines includes two main purposes: the first one is the Error Field Correction (EFC). The EFC aims at minimizing the intrinsi ...

Elsevier Science Sa2023

Fast 3D Modeling of Prosthetic Robotic Hands Based on a Multi-Layer Deformable Design

Daniel Thalmann

Current research of designing prosthetic robotic hands mainly focuses on improving their functionality by devising new mechanical structures and actuation systems. Most of existing work relies on a single structure/system (e.g., bone-only or tissue-only) a ...

WHIOCE PUBLISHING PTE LTD, SINGAPORE2022

Synthesis and Analysis of 3D shapes with Geometric Deep Learning in Computer-Aided Engineering

Edoardo Remelli

In this thesis, we advocate that Computer-Aided Engineering could benefit from a Geometric Deep Learning revolution, similarly to the way that Deep Learning revolutionized Computer Vision. To do so, we consider a variety of Computer-Aided Engineering pr ...

EPFL2022

Image-based geometric digital twinning for stone masonry elements

Katrin Beyer, Bryan German Pantoja Rosero, Savvas Saloustros

We present an image-based pipeline for generating geometrical digital twins (GDTs) of stone masonry elements with detail down to the stone level. For this purpose, we acquire RGB images of the individual stones and of the wall during the construction phase ...

2022

Bragg edge tomography characterization of additively manufactured 316L steel

Christian Leinenbach, Roland Logé, Nikola Kalentics, Efthymios Polatidis, Markus Strobl

In this work we perform a neutron Bragg edge tomography of stainless steel 316L additive manufacturing samples, one as built via standard laser powder bed fusion, and one using the novel three-dimensional (3D) laser shock peening technique. First, we consi ...

AMER PHYSICAL SOC2022

Towards an in vitro cardiac model: 3D environment, co-culture, alignment, and mechanical stimulation impact on cell behavior

Fatemeh Navaee

Our aim is to develop a 3D model unit of cardiac muscle: an in-vitro analog of the trabeculae carneae found in vivo. As a base hydrogel matrix for cardiomyocyte culture in 3D, we develop a blend of decellularized extracellular matrix (dECM) and fibrin. Thi ...

EPFL2021

Bioprinting of Cartilaginous Auricular Constructs Utilizing an Enzymatically Crosslinkable Bioink

Philipp Fisch, Nicolas Antoine Vincent Broguiere

Bioprinting of functional tissues could overcome tissue shortages and allow a more rapid response for treatments. However, despite recent progress in bioprinting, and its outstanding ability to position cells and biomaterials in a precise 3D manner, its su ...

WILEY-V C H VERLAG GMBH2021

Mechanical principles of engineering fibrous tissues with programmable shape

Erik Mailand

The form and structure of biological tissues define their function. The emergence of tissue morphology during development is one of the wonders of nature. Cells mechanically probe and manipulate their surroundings while constructing structures from the ext ...

EPFL2021

Engineering next generation organoids through guided stem cell self-organisation

Mikhail Nikolaev

One of the long-standing goals in the field of tissue engineering is the fabrication of de novo tissues or even organs to provide better tissue models for basic research and drug discovery, and to alleviate a shortage of donor organs in the future. Researc ...

EPFL2021

Megapixel SPAD cameras for time-resolved applications

Kazuhiro Morimoto

Progress in optics technology has enriched our daily lives in many ways. Various types of single-photon detector technologies have emerged in the last century. Among these, single-photon avalanche diode (SPAD) technology outperforms other detectors for its ...

EPFL2020

Grayscale e-beam lithography: Effects of a delayed development for well-controlled 3D patterning

Henning Paul-Julius Stahlberg

Grayscale electron beam lithography (g-EBL) is a fabrication technique that allows for tunable control of resist topography. In most cases, the height of the structures is in the submicron regime. Here, we present an extensive experimental characterization ...

2020

A model for 3D deformation and reconstruction of contractile microtissues

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Jaemin Kim

Tissue morphogenesis and regeneration are essentially mechanical processes that involve coordination of cellular forces, production and structural remodeling of extracellular matrix (ECM), and cell migration. Discovering the principles of cell–ECM interact ...

2020

3D Printed Micro-Scaffolds Loaded by Inkjet Printing With in-Precise Amount of Drug

Jürgen Brugger, Christopher Chi Wai Tse, Jongmoon Jang, Fengyi Zheng

We propose a novel combination of two-photon polymerization (2PP) three-dimensional (3D) micro-manufacturing with drop-on-demand inkjet printing (DOD IJP) to fabricate 3D microporous scaffolds embedded with minute quantities of releasable drug. We designed ...

IEEE2020

Voxel2Mesh: 3D Mesh Model Generation from Volumetric Data

Pascal Fua, Graham Knott, Pamuditha Udaranga Wickramasinghe, Edoardo Remelli

CNN-based volumetric methods that label individual voxels now dominate the field of biomedical segmentation. However, 3D surface representations are often required for proper analysis. They can be obtained by post-processing the labeled volumes which typic ...

2020

Brain micro-vasculature imaging: An unsupervised deep learning algorithm for segmenting mouse brain volume probed by high-resolution phase-contrast X-ray tomography

Anne Bonnin, Alessandra Patera, Marco Stampanoni

High-throughput synchrotron-based tomographic microscopy at third generation light sources allows to probe cm-sized samples at micrometer-resolution. In this work, we present an approach to image a full mouse brain. With Indian-ink as a contrast agent, it ...

WILEY2021