Exploring the mechanisms governing nuclear cGAS localization and activity

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Base excision repair enzymes (BERs) detect and repair oxidative DNA damage with efficacy despite the small size of the defects and their often only minor structural impact. A charge transfer (CT) model for rapid scanning of DNA stretches has been evoked to ...

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DNA-binding proteins physically interact with the DNA and directly affect genomic functions. The eukaryotic genome is compacted into chromatin, limiting the DNA access to nuclear factors. In this Ph.D. thesis, I explored the dynamic mechanisms, that allow ...

Cancer immunotherapy has become an attractive strategy among different therapeutic modalities over the past few years and has showed great success in the clinic. However, there are many outstanding challenges hindering the current immunotherapies. In my Ph ...

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PremiseA novel protocol for rapid plant DNA extraction using microneedles is proposed, which supports botanic surveys, taxonomy, and systematics. This protocol can be conducted in the field with limited laboratory skills and equipment. The protocol is vali ...

Exploring the mechanisms governing nuclear cGAS localization and activity

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Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Dynamics of CLIMP-63 S-acylation control ER morphology

Molecular mechanism of plasmid elimination by the DdmDE defense system

Development of stimuli-responsive chemistry for tumor-targeted immunotherapy

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

Oxidative Defect Detection Within Free and Packed DNA Systems: A Quantum Mechanical/Molecular Mechanics (QM/ MM) Approach

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

Functional characterization of Drosophila melanogaster immune effectors

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Chromosome organization shapes replisome dynamics in Caulobacter crescentus

Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Tracking spatiotemporal localisation and interactions of the innate immune sensor STING

Development of multiplexed single-molecule imaging techniques to study chromatin invasion dynamics of chromatin effector proteins

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical surveying and monitoring