Publication

Trifluoromethyl-substituted pyridines through displacement of iodine by in situ generated (trifluoromethyl)copper

Manfred Schlosser, Fabrice Cottet
2002
Journal Articles

Abstract

A literature method reported for the prepn. of trifluoromethyl substituted benzenes from iodobenzene and congeners was successfully extended to the pyridine series. 2-Iodopyridines can be converted into 2-(trifluoromethyl)pyridines almost quant. by displacement of iodide by (trifluormethyl)copper generated in situ from (trifluoromethyl)trimethylsilane in the presence of cuprous iodide and potassium fluoride. In contrast, yields are moderate at best if 3- and 4-iodopyridines or 2-bromopyridines are used as the starting materials. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/5d42e47c-1e6b-4de3-8e50-fc7651676c14

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Manfred Schlosser, Fabrice Cottet
2002
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/5d42e47c-1e6b-4de3-8e50-fc7651676c14

About this result

Related concepts (32)

Pyridine

Pyridine is a basic heterocyclic organic compound with the chemical formula . It is structurally related to benzene, with one methine group replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Pyridine is colorless, but older or impure samples can appear yellow, due to the formation of extended, unsaturated polymeric chains, which show significant electrical conductivity.

Copper

Copper is a chemical element with the symbol Cu (from cuprum) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pinkish-orange color. Copper is used as a conductor of heat and electricity, as a building material, and as a constituent of various metal alloys, such as sterling silver used in jewelry, cupronickel used to make marine hardware and coins, and constantan used in strain gauges and thermocouples for temperature measurement.

Copper extraction

Copper extraction refers to the methods used to obtain copper from its ores. The conversion of copper ores consists of a series of physical, chemical and electrochemical processes. Methods have evolved and vary with country depending on the ore source, local environmental regulations, and other factors. The Old Copper Complex in North America has been radiometrically dated to 9500 BP—i.e., about 7480 BCE—making it one of the oldest known examples of copper extraction in the world.