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A mild and general method for the selective cleavage of anti-1,3-acetonides has been developed for the differentiation of 1,3-anti and 1,3-syn diols in long chain polyolic fragments. The diluted acidic conditions applied to these systems are compatible with other common protecting groups such as silyl ethers and benzyloxymethyl ethers.
Pierre Vogel, Maris Turks, Dean Markovic
Paul Joseph Dyson, Gabor Laurenczy, Weijia Gan