New 1-amino-1-deoxy- and 2-amino-2-deoxy-polyhydroxyazepanes: synthesis and inhibition of glycosidases

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Related publications (28)

Freestanding Silicon Photonic Ring and Disk Resonators

Niels Quack, Hamed Sattari, Alain Yuji Takabayashi, Yu Zhang

We report freestanding silicon photonic ring and disk resonators fabricated in a simplified silicon photonics process based on IMEC's iSiPP5OG standard platform that have been released by a custom MEMS post-processing step. Experimental results show high o ...

IEEE2019

Photoredox-Catalyzed Decarboxylation for the Transfer of Alkynes and Nitriles Using Hypervalent Iodine Reagents

Franck Le Vaillant

Aliphatic alkynes and nitriles are privileged motifs in organic chemistry. Therefore, alkynes and nitriles have played a central role for the exploration and development of novel strategies to forge C-C bonds in efficient manner. They are broadly used as v ...

EPFL2019

A Sensor Network Architecture for Digital SiPM-Based PET Systems

Claudio Bruschini, Edoardo Charbon, Francesco Gramuglia

Digital silicon photo-multipliers (SiPMs) have emerged in the recent past as a viable low cost alternative to photomultiplier tubes in positron emission tomography systems, providing multiple timestamps, energy and scintillation coordinates at high spatial ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2018

Atomistic simulation of bio-relevant ionic and organic species interacting with rutile - Towards the understanding of apatite formation

Azade Yazdan Yar

Atomistic simulation methods, namely molecular dynamics and well-tempered metadynamics, are used in this thesis to investigate apatite formation from different aspects. First, ions which are more abundant in SBFs under physiological conditions were identif ...

EPFL2018

Catalytic amino acid production from biomass-derived intermediates

Paul Joseph Dyson, Ning Yan, Yu Han, Yefeng Wang, Shunlin Zhang

Amino acids are the building blocks for protein biosynthesis and find use in myriad industrial applications including in food for humans, in animal feed, and as precursors for bio-based plastics, among others. However, the development of efficient chemical ...

National Academy of Sciences2018

Decarboxylative C(sp3)–N cross-coupling via synergetic photoredox and copper catalysis

Xile Hu, Adrian Frey, Jonathan Balon, Runze Mao

Amines are a quintessential moiety in bioactive molecules, pharmaceuticals and organic materials. Transition-metal-catalysed C–N coupling of aryl electrophiles has been established as a powerful and reliable method for amine synthesis. However, the analogo ...

2018

Development of cyclic peptide inhibitors of coagulation factor XII and matrix metalloproteinase 2

Jonas Alfred Karl Wilbs

Peptides represent a promising molecular class for drug development. They combine several strengths of small molecules (e.g. efficient tissue diffusion, low immunogenicity and access to chemical synthesis) and key properties of biologics such as monoclonal ...

EPFL2018

Homogeneous Catalytic Formic Acid Dehydrogenation in Aqueous Solution using Ruthenium Arene Phosphine Catalysts

Gabor Laurenczy, Cornel Fink, Lu Chen

In this work, we studied catalytic formic acid dehydrogenation with a homogeneous RAPTA type precatalyst in aqueous solution. The effects of an amino group, attached to the arene, and the impact of a second equivalent of 1,3,5‐triaza‐7‐phosphaadamantane (P ...

2018

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