Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

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A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...

Spinal cord injury (SCI) interrupts axonal connections between the brain and the spinal cord, and is characterized by a spectrum of sensorimotor and autonomic impairments. While spontaneous recovery is limited, recent studies have shown that functional imp ...

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

How the neocortex modulates hindbrain and spinal circuits is of fundamental interest for understanding mo-tor control and adaptive behaviors. New work from Yang, Kanodia, and Arber demonstrates that there is an exquisite anatomical organization and functio ...

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

Human-machine interfaces (HMIs) can be used to decode a user's motor intention to control an external device. People that suffer from motor disabilities, such as spinal cord injury, can benefit from the uses of these interfaces. While many solutions can be ...

Locomotion is based on a sophisticated interaction among the environment, the musculoskeletal system, the spinal cord, and the brain locomotor areas. Quality of life is strongly related to the proper capability of this movement. However, many pathologies, ...

Spinal Cord Injury (SCI) results in damage to neural circuitry connecting the brain to the periphery. Consequently, sensory and motor function is lost, to varying degree, depending on the site and severity of the lesion. More than half of spinal cord injur ...

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

Objective. Meralgia paresthetica (MP) is a mononeuropathy of the exclusively sensory lateral femoral cutaneous nerve (LFCN) that is difficult to treat with conservative treatments. Afferents from the LFCN enter the spinal cord through the dorsal root entry ...

Methanation can be applied as part of a Power-to-Gas (PtG) concept to store renewable electricity. Using a catalytic bubbling fluidized bed (BFB) methanation reactor allows a flexible and economic operation. Properties of bubbles rising through the fluidiz ...

We consider three-dimensional cubic barcodes, consisting of smaller cubes, each built from one of two possible materials and carry one bit of information. To retrieve the information stored in the barcode, we measure a 2-D projection of the barcode using a ...

Objectives Fluid and white matter suppression (FLAWS) is a recently proposed magnetic resonance sequence derived from magnetization-prepared 2 rapid acquisition gradient-echo providing 2 coregistered datasets with white matter- and cerebrospinal fluid-supp ...

High-throughput synchrotron-based tomographic microscopy at third generation light sources allows to probe cm-sized samples at micrometer-resolution. In this work, we present an approach to image a full mouse brain. With Indian-ink as a contrast agent, it ...

Quantitative phase imaging (QPI) is an emerging label-free technique that produces images containing morphological and dynamical information without contrast agents. Unfortunately, the phase is wrapped in most imaging system. Phase unwrapping is the comput ...

Neurological disorders such as spinal cord injury (SCI) massively reduce independence and quality of life. Most often, the majority of the nervous system is still fully or partially spared, but dysfunctional due to aberrant or absent descending input from ...

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

Spinal cord injury (SCI) is a life-changing event. People who suffer from it lose their ability to move normally and are subject to life-threatening symptoms. When the insult is not too severe, partial recovery is possible. Otherwise, for severely affected ...

Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively b ...

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

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Multimodal transcriptomic atlases of mouse spinal cord injury

Digital reconstruction of the mammalian spinal cord: from anatomical reference volume to cell type atlas of the mouse spinal cord

Targeted regeneration of spinal cord neurons across a complete injury restores walking

Walking naturally after spinal cord injury using a brain-spine interface

Reaching an understanding of cortico-medullary control of forelimb behaviors

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Human-machine interface for two-dimensional steering control with the auricular muscles

Investigating the neuromechanical control of healthy gait modulation and pathological gaits observed in cerebral palsy using neuromuscular simulations

Sensor-based control strategies for integration of epidural electrical stimulation in rehabilitation after spinal cord injury

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Targeted dorsal root entry zone stimulation alleviates pain due to meralgia paresthetica

Cross verified independent measurements of correlated bubble property distributions as part of the scale-up of a catalytic bubbling fluidized bed reactor

Three-Dimensional Cubic Barcodes

3-Dimensional Fluid and White Matter Suppression Magnetic Resonance Imaging Sequence Accelerated With Compressed Sensing Improves Multiple Sclerosis Cervical Spinal Cord Lesion Detection Compared With Standard 2-Dimensional Imaging

Brain micro-vasculature imaging: An unsupervised deep learning algorithm for segmenting mouse brain volume probed by high-resolution phase-contrast X-ray tomography

Robust Phase Unwrapping via Deep Image Prior for Quantitative Phase Imaging

Electrical spinal cord stimulation protocols to regulate motor and autonomic functions in people with neurological disorders

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Electrical spinal cord stimulation protocols to regulate neurological functions after spinal cord injury

Modeling spinal locomotor circuits for movements in developing zebrafish