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How the neocortex modulates hindbrain and spinal circuits is of fundamental interest for understanding mo-tor control and adaptive behaviors. New work from Yang, Kanodia, and Arber demonstrates that there is an exquisite anatomical organization and functional modulation from the anterior (motor) cortex on downstream medulla populations during forelimb behaviors in mice.
Andreas Pautz, Vincent Pierre Lamirand, Mathieu Hursin, Oskari Ville Pakari, Pavel Frajtag, Axel Guy Marie Laureau, Fanny Vitullo, Adolfo Rais, Nicolas Weiss, Thomas Jean-François Ligonnet, Daniel Godat, Klemen Ambrozic