The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

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The success of chimeric antigen receptor (CAR) T cell therapy in treating several hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of T cell exhaustion and eventually dysfunction. To counter T cell dysfunction in ...

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The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

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