IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

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The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene-modified T cells. Split ON- or OFF-switch CARs involve the dissociation of tumor–antigen binding from T cell ...

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One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3+CD8+ T cell-inflamed tumors typically show better response to immune ...

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Background Activin-A, a transforming growth factor beta family member, is secreted by many cancer types and is often associated with poor disease prognosis. Previous studies have shown that Activin-A expression can promote cancer progression and reduce the ...

Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...

Simple Summary Breast cancer stem cells are a subset of transformed cells that sustain tumor growth and can metastasize to secondary organs. Since metastasis accounts for most cancer deaths, it is of paramount importance to understand the cellular and mole ...

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The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24 h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regula ...

Vaccination has been regarded to as the most attractive immunotherapy for cancer because of its ability to instruct immune cells to recognize and kill tumor cells. Exosomes are one of the most recent discoveries translated from basic biology into experimen ...

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Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator of immune responses and therefore an important therapeutic target for the treatment of diseases that involve pathological immune escape, such as cancer. Here, we describe a robust and sensitive high-t ...

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

Lymphatic vessels surround follicles within the ovary, but their roles in folliculogenesis and pregnancy, as well as the necessity of Lymphangiogenesis in follicle maturation and health, are undefined. We used systemic delivery of mF4-31C1, a specific anta ...

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

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IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

Stem cells and the circadian clock

Bioengineering approaches in immunotherapy : from basic to translational applications

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Experimental peripheral arterial disease: new insights into muscle glucose uptake, macrophage, and T-cell polarization during early and late stages

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies : Tuberculosis, Lung Metastasis and Allergy as Models

In situ cell manipulation through enzymatic hydrogel photopatterning

VEGFR-3 Neutralization Inhibits Ovarian Lymphangiogenesis, Follicle Maturation, and Murine Pregnancy