Publication

A reproducible method for μm precision alignment of PDMS microchannels with on-chip electrodes using a mask aligner

Philippe Renaud, Jonathan Bastien Cottet
2017
Journal Articles

Abstract

This paper describes a reproducible method for μm precision alignment of polydimethylsiloxane (PDMS) microchannels with coplanar electrodes using a conventional mask aligner for lab-on-a-chip applications. It is based on the use of a silicon mold in combination with a PMMA sarcophagus for precise control of the parallelism between the top and bottom surfaces of molded PDMS. The alignment of the fabricated PDMS slab with electrodes patterned on a glass chip is then performed using a conventional mask aligner with a custom-made steel chuck and magnets. This technique allows to bond and align chips with a resolution of less than 2 μm.

Official source

https://infoscience.epfl.ch/entities/publication/52865eb4-6430-42c8-bd2c-0f5a768a8a23

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Philippe Renaud, Jonathan Bastien Cottet
2017
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/52865eb4-6430-42c8-bd2c-0f5a768a8a23

About this result

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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context.

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A reproducible method for μm precision alignment of PDMS microchannels with on-chip electrodes using a mask aligner

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