Perfluorinated ruthenium(II) complexes with improved anti-angiogenic or anti-cancer activity

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Ruthenium(II) arene complexes of 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP) were obtained. Cytotoxicity studies against cancer cell lines reveal higher activity than the corresponding PTA analogues and, in comparison to the effects on noncancer ...

The cyclopentadienyl (Cp) group is a very important ligand for many transition-metal complexes which have been applied in catalysis. The availability of chiral cyclopentadienyl ligands (Cp-x) lags behind other ligand classes, thus hampering the investigati ...

Photodynamic therapy (PDT) is an effective clinical treatment for a number of different cancers. PDT can induce hypoxia and inflammation, pro-angiogenic side effects, which may counteract its angio-occlusive mechanism. The combination of PDT with anti-angi ...

Hqpzc has been synthesized by a highly efficient procedure using the ionic liquid TBAB as an environmentally benign reaction medium. [Cu(qpzc)(OAc)]H2O (1) and [Zn(qpzc)(OAc)(H2O)] (2), complexes of the deprotonated ligand, qpzc [qpzc ...

A series of cationic dinuclear p-cymene ruthenium complexes containing three thiolato bridges with different substituents at the sulfur atoms, (eta(6)-p-(MeC6H4Pr)-Pr-i)(2)Ru-2(mu(2)-SR1)(2)(mu(2)-SR2) (R-1 = CH2Ph, R-2 = Ph: 4; R-1 = CH2Ph, R-2 = p-( ...

The arene osmium metalla-prism (p-cymene)(6)Os-6(donq)(3)(tpt)(2) (2) (donq 5,8-dioxydo-1,4-naphthoquinonato, tpt 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine) has been prepared from the dinuclear arene osmium precursor [(p-cymene)(2)Os-2(donq)Cl-2] ...

Perfluorinated ruthenium(II) complexes with improved anti-angiogenic or anti-cancer activity

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Synthesis, characterization and in vitro anticancer activity of highly cytotoxic trithiolato diruthenium complexes of the type [(eta(6)-p-(MeC6H4Pr)-Pr-i)(2)Ru-2(mu(2)-SR1)(2)(mu(2)-SR2)](+) containing different thiolato bridges

Encapsulation of inorganic and organic guest molecules into an organometallic hexacationic arene osmium metalla-prism: Synthesis, characterisation and anticancer activity