Contractile Tail Machines of Bacteriophages

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Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced and oxidized glutathione. In eukaryotic cells, this ratio is different ...

The bacterial inactivation kinetics of Escherichia coli (E. coli) by innovative sputtered TiMoON and TiMoON-Ag films under simulated solar light irradiation is accounted for in a detailed, comprehensive and systematic form. This study presents the evidence ...

Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...

Mycobacterium tuberculosis (Mtb) infection is initiated by inhalation of bacteria into lung alveoli, where they are phagocytosed by resident macrophages. Intracellular Mtb replication induces the death of the infected macrophages and the release of bacteri ...

The human gut microbiota plays a central role in intestinal health and disease. Yet, many of its bacterial constituents are functionally still largely unexplored. A crucial prerequisite for bacterial survival and proliferation is the creation and/or exploi ...

Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...

We present two open-source Python packages: "electron spectro-microscopy"(espm) and "electron microscopy tables"(emtables). The espm software enables the simulation of scanning transmission electron microscopy energy-dispersive X-ray spectroscopy datacubes ...

Bacteria often colonize their environment in the form of surface attached multicellular communities called biofilms. Biofilms grow from surface-attached cells that undergo division while self-embedding in a viscoelastic matrix. Biofilms grow at the surface ...

Eukaryotic organisms play an important role in industrial biotechnology, from the production of fuels and commodity chemicals to therapeutic proteins. To optimize these industrial systems, a mathematical approach can be used to integrate the description of ...

This paper evaluated the use of soft-probe scanning electrochemical microscopy complementarily with confocal laser scanning microscopy to study the effects of different antimicrobial agents and treatments on E. coli DH5α biofilm. The antimicrobial agents w ...

The beginning of the 21st century was marked by the advent of disruptive technologies, which ushered an era of groundbreaking advances in fundamental sciences, carried by the great pace at which computational capabilities spread and evolved. But the new ce ...

This protocol comprises various methods to coculture organoids (particularly human small intestinal and colon organoids) with microbes, including microinjection into the lumen and periphery of 3D organoids and exposure of organoids to microbes in a 2D laye ...

The notion that mitochondria cannot be lost was shattered with the report of an oxymonad Monocercomonoides exilis, the first eukaryote arguably without any mitochondrion. Yet, questions remain about whether this extends beyond the single species and how th ...

A fundamental question of eukaryotic cell biology is how membrane organelles are organised and interact with each other. Cell biologists address these questions by characterising the structural features of membrane compartments and the mechanisms that coor ...

Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...

The bacteriophage T4 genome contains two genes that code for proteins with lysozyme activity-e and 5. Gene e encodes the well-known T4 lysozyme (commonly called T4L) that functions to break the peptidoglycan layer late in the infection cycle, which is requ ...

The biofilm lifestyle is the most widespread survival strategy in the bacterial world. Pseudomonas aeruginosa biofilms cause chronic infections and are highly recalcitrant to antimicrobials. The genetic requirements allowing P. aeruginosa to grow into biof ...

Contractile Tail Machines of Bacteriophages

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Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe

Bacterial inactivation on sputtered TiOMoN and TiOMoN-Ag thin films under solar simulated light

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates

Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader

A minimalistic cyclic ice-binding peptide from phage display

espm: A Python library for the simulation of STEM-EDXS datasets

Biofilm morphogenesis on soft hydrogels

A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics

Revealing the Effects of Three Different Antimicrobial Agents on E. coli Biofilms by Using Soft-Probe Scanning Electrochemical Microscopy

New and improved methods for integrated models of metabolism and gene expression

Intestinal organoid cocultures with microbes

Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria

Mammalian membrane trafficking as seen through the lens of bacterial toxins

Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery

Structure and Function of the T4 Spackle Protein Gp61.3

Material Substrate Physical Properties Control Pseudomonas aeruginosa Biofilm Architecture