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V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

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SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Loïc Dayon, Andreas Wiederkehr

Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...

COMPANY BIOLOGISTS LTD2023

Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells

Cyrus Kazemiraad

Vimentin is a main type 3 intermediate filament protein. It seems that abnormal expression of vimentin is contributed to the appearance of the aggressive feature of cancer cells. So that it has been reported that malignancy and epithelial-mesenchymal trans ...

SPRINGER2023

Dissecting the role of the mitochondrial carrier SLC25A47

Nadia Bresciani

Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological relevance as gatekee ...

EPFL2022

Telomere protection against oxidative stress

Thu Trang Nguyen

Telomeres are nucleoprotein structures at the ends of linear chromosomes, being essential for the maintenance of genomic integrity. Telomeres have a unique structure which distinguishes chromosome termini from DNA damage sites. Shelterin complexes are the ...

EPFL2023

Overcoming decision paralysis—A digital twin for decision making in energy system design

François Maréchal, Julia Granacher, Tuong-Van Nguyen

The design of efficient energy systems, through the development of new technologies and the improvement of current ones, requires the use of rigorous process synthesis methods for generating and analysing design alternatives. We introduce a digital twin of ...

2022

Type-Preserving Compilation of Class-Based Languages

Guillaume André Fradji Martres

The Dependent Object Type (DOT) calculus was designed to put Scala on a sound basis, but while DOT relies on structural subtyping, Scala is a fundamentally class-based language. This impedance mismatch means that a proof of DOT soundness by itself is ...

EPFL2023

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Jun Yong Kim, Maroun Bou Sleiman, Xiaoxu Li

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

Nature Portfolio2023

Improved framework to estimate travel time and derived distributions in hydrological control volumes

Mitra Asadollahi

Crossing properties of soil saturation, defined as the duration and excursion of soil saturation below and above certain thresholds, are key variables to ecosystem functioning and evolution by primarily influencing the plant and soil microbes physiological ...

EPFL2022

Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis

Christopher Tadhg James Wall

Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...

EPFL2022

Computational Studies of the Proton-Coupled Metal Ion Transport in the SLC11/NRAMP Family of Transporters

Maria Letizia Merlini

In the last years, it has been demonstrated a link between the overload of metal ions inside nervous system cells and the onset of severe neurodegenerative diseases. This prompted the investigation of the structural and functional properties of transporter ...

EPFL2022

System for planning and/or providing neuromodulation

Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Vincent Delattre, Karen Minassian

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includesa stimulation related basic data storage module for storing stimulation related basic data,a stimulation related response data sto ...

2021

Discourse Phenomena in Machine Translation

Lesly Sadiht Miculicich Werlen

Machine Translation (MT) has made considerable progress in the past two decades, particularly after the introduction of neural network models (NMT). During this time, the research community has mostly focused on modeling and evaluating MT systems at the se ...

EPFL2021

Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe

Pablo Rivera Fuentes, Jade Noémie Nam Nguyen

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced and oxidized glutathione. In eukaryotic cells, this ratio is different ...

ROYAL SOC CHEMISTRY2021

On the ‘cultural transfer’ of modern architecture northwards - Akzeptiere: Das Buch und seine Geschichte

Chiara Monterumisi

"Akzeptiere: Das Buch und seine Geschichte" is the latest in-depth contribution by Atli Magnus Seelow, one of several by him on the 1930 Stockholm exhibition and the book accepetera, the 200-page text often referred to as ‘the manifesto of Swedish function ...

2021

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Sebastian Maerkl, Ragunathan Bava Ganesh

Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of t ...

FRONTIERS MEDIA SA2022