Graphene nanowalls for high-performance chemotherapeutic drug sensing and anti-fouling properties

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Foundation models have become a powerful tool in single-cell transcriptomics, enabling broad generalization across tasks such as cell type annotation, data integration, and drug response prediction. Yet, most current models are trained predominantly on hea ...

Graphene transfer methods either employ support layers that have to be removed after transfer, giving rise to impurities, or are based on delamination from bulk crystals, yielding only small flakes with various thicknesses. We present a graphene transfer m ...

Tuning the reactivity of graphene enables molecular-level engineering of the lattice, achieving desired chemical and structural properties through functionalization, doping, and etching. Atom-thin graphene film hosting Å-scale pores, with capability to dif ...

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The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

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Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...

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Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...

The earth-abundant and non-toxic material Zinc phosphide (Zn3P2) is a promising candidate for solar cell applications. However, growth of defect-free, high-quality thin films on substrates that can integrate with current technology (e.g. silicon) remains c ...

Ozonation of natural waters is typically associated with the formation of carbonyl compounds (aldehydes, ketones and ketoacids), a main class of organic disinfection byproducts (DBPs). However, the detection of carbonyl compounds in water and wastewater is ...

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Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus's spike protein and ce ...

Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years ...

Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the prevalence and the clinical and biological implications of histone gene mutations in malignant tumors remain ...

Graphene nanowalls for high-performance chemotherapeutic drug sensing and anti-fouling properties

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Abstract IA02: Cancer-specific foundation models: Friend or foe in healthcare AI?

Large Area Monolayer Graphene Transfer in Ultra-High Vacuum

Modulation of Graphene Oxidation Using Substrate-Induced Electron-Hole Puddles for Advancing Molecular Separation

CO Adsorption Dynamics during CO2 Electrolysis in Aprotic Organic Electrolytes

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Mechanism of KRAS-driven T cell infiltration in colorectal cancer

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Improved microfluidic transcriptome based screening methods

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Methods for high-throughput synthesis and screening of peptide libraries

Towards Quantitative Terahertz Characterisation of Zinc Phosphide Thin Films for Photovoltaic Applications

Formation of carbonyl compounds during ozonation of lake water and wastewater: Development of a non-target screening method and quantification of target compounds

Mobility Gaps of Hydrogenated Amorphous Silicon Related to Hydrogen Concentration and Its Influence on Electrical Performance

Screening for drivers of SARS-CoV-2 uptake

Cyclic Peptides for Drug Development

Pan-cancer atlas of somatic core and linker histone mutations