Calculation of intracranial pressure in human brain using Darcy's and Biot's models

Cerebrospinal fluid (CSF) is a colourless liquid that fills the ventricular space and serves several functions like buoyancy, chemical stability and protection. CSF is produced within the ventricles and partly by the ependyma cells. Part of it seeps towards the brain parenchyma where it is partially absorbed by the blood venous system. CSF flow disturbances lead to different brain diseases such as obstructive, communicating or normal pressure hydrocephalus (NPH). It is primordial to assess the influence of the CSF seepage through the ventricles towards the parenchyma on the ventricle deformation in a normal brain before studying the pathogenesis of NPH.