Publications related to Conversion of cyclosporine A prodrugs in human tears vs rabbits tears

Related publications (32)

Reactivity of Cyanobacteria Metabolites with Ozone: Multicompound Competition Kinetics

Cyanobacterial blooms occur at increasing frequency and intensity, notably in freshwater. This leads to the introduction of complex mixtures of their products, i.e., cyano-metabolites, to drinking water treatment plants. To assess the fate of cyano-metabol ...

Amer Chemical Soc2024

Oxidation processes and me

Urs von Gunten

This publication summarizes my journey in the field of chemical oxidation processes for water treatment over the last 30+ years. Initially, the efficiency of the application of chemical oxidants for micropollutant abatement was assessed by the abatement of ...

Pergamon-Elsevier Science Ltd2024

Chlorination of amides: Kinetics and mechanisms of formation of N-chloramides and their reactions with phenolic compounds

Urs von Gunten, Tianqi Zhang

Amides are common constituents in natural organic matter and synthetic chemicals. In this study, we investi-gated kinetics and mechanisms of the reactions of chlorine with seven amides, including acetamide, N-meth-ylformamide, N-methylacetamide, benzamide, ...

2023

Development of next-generation microfluidic systems for enhanced, faster, and cost-effective immunoassays for tissue diagnostics - Ac electrothermal flow & Acoustofluidics

Muaz Salama Abdelmonem Draz

The application of microfluidics in the field of surface-based assays and more specifically, the spatial molecular profiling of tumor tissues has gained a lot of interest, especially with the increased interest in personalized medicine and targeted therapy ...

EPFL2023

Assessing the value of kinetic results from biochemical methane potential tests: Reproducibility from a large inter-laboratory study

Christof Holliger

Kinetic information extracted from biochemical methane potential (BMP) tests is often reported but its value is unclear. Inter-laboratory reproducibility provides a useful indication of its value. Here we extracted estimates of the first-order rate constan ...

2022

Flowing Gas Experiments Reveal Mechanistic Details of Interfacial Reactions on a Molecular Level at Knudsen Flow Conditions

Christian Ludwig, Michel Rossi, Riccardo Iannarelli

Knudsen flow experiments and its interpretation in terms of adsorption/desorption kinetics as well as quantitative uptake on substrates of interest is presented together with the description of critical design parameters of the Knudsen Flow Reactor (KFR). ...

2022

Oxidation of organic micropollutant surrogate functional groups with peracetic acid activated by aqueous Co(II), Cu(II), or Ag(I) and geopolymer-supported Co(II)

Urs von Gunten

Peracetic acid (PAA) in combination with transition metals has recently gained increasing attention for organic micropollutant abatement. In this study, aqueous Co(II), Cu(II), and Ag(I) were compared for their capacity to activate PAA. Co(II) outperformed ...

PERGAMON-ELSEVIER SCIENCE LTD2022

The influence of sulfate addition on hydration kinetics and C-S-H morphology of C3S and C3S/C(3)A systems

Karen Scrivener, Franco Alberto Zunino Sommariva

A comprehensive understanding of hydration kinetics, sulfate requirement and phase assemblage of Portland cement is crucial for further optimization of early-age performance, especially when part of cement is replaced by mineral additions in blended cement ...

Pergamon-Elsevier Science Ltd2022

Photochemical oxidation of phenols and anilines mediated by phenoxyl radicals in aqueous solution

Urs von Gunten, Stephanie Christa Remke

Reactive intermediates formed upon irradiation of chromophoric dissolved organic matter (CDOM) contribute to the degradation of various organic contaminants in surface waters. Besides well-studied "short-lived" photo oxidants, such as triplet state CDOM (3 ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Carboxymethyl cellulose nanocomposite beads as super-efficient catalyst for the reduction of organic and inorganic pollutants

Shaik Mohammed Zakeeruddin

Carboxymethyl cellulose/copper oxide-nickel oxide (CMC/CuO-NiO) nanocomposite beads were prepared by facile, simple and environmentally friendlymethod. Initially, CuO-NiOwas prepared and applied for the catalytic reduction of 4-nitrophenol (4-NP). The resu ...

ELSEVIER2021

Two-step immobilization of metronidazole prodrug on TEMPO cellulose nanofibrils through thiol-yne click chemistry for in situ controlled release

David Lyndon Emsley, Jasmine Viger-Gravel

Nowadays, drug encapsulation and drug release from cellulose nanofibrils systems are intense research topics, and commercial grades of cellulose nanomaterials are currently available. In this work we present an ester-containing prodrug of metronidazole tha ...

ELSEVIER SCI LTD2021

Systematic investigations of uranium carbide composites oxidation from micro- to nano-scale: Application to waste disposal

Nhât-Tân Vuong

The production of radioisotope beams at the ISOLDE (Isotope Separator OnLine DEvice) facility at CERN is achieved by irradiating target materials (e.g. uranium carbides and metal foils) with protons. The materials are usually operated at temperatures above ...

EPFL2021

Gold-in-copper at low *CO coverage enables efficient electromethanation of CO2

Michael Graetzel, Dan Ren, Jun Li

The renewable-electricity-powered CO2 electroreduction reaction provides a promising means to store intermittent renewable energy in the form of valuable chemicals and dispatchable fuels. Renewable methane produced using CO2 electroreduction attracts inter ...

Nature Research2021

In-core dosimetry for the validation of neutron spectra in the CROCUS reactor

Andreas Pautz, Vincent Pierre Lamirand, Pavel Frajtag, Axel Guy Marie Laureau

The present article describes the preliminary validation study of simulated in-core and reflector n eutron spectra in preparation of oncoming experimental programs in the zero-power reactor CROCUS at EPFL. For this purpose, a set of activation foils were i ...

E D P SCIENCES2020

Imaging Catalysis: Operando Investigation of the CO2 Hydrogenation Reaction Dynamics by Means of Infrared Thermography

Andreas Züttel, Emad Oveisi, Kun Zhao, Loris Giovanni Lombardo, Robin Tobias Andreas Mutschler, Emanuele Moioli

Infrared thermography is a powerful tool to investigate the dynamic evolution of temperature in chemical reactions. The CO2 hydrogenation reaction is an ideal model reaction to assess the presented technique due to its high exothermicity. Various dynamic e ...

AMER CHEMICAL SOC2020

Power calibration methodology at the CROCUS reactor

Andreas Pautz, Vincent Pierre Lamirand, Oskari Ville Pakari, Pavel Frajtag, Axel Guy Marie Laureau

In the present article, we detail the method used to experimentally determine the power of the CROCUS zero-power reactor, and to subsequently calibrate its ex-core monitor fission chambers. Knowledge of the reactor power is a mandatory quantity for a safe ...

E D P SCIENCES2020

Functional and Responsive Polymers via Controlled Radical Polymerization

Jian Wang

This Thesis is built around 4 topics, which share in common that they all take advantage of the assets of controlled radical polymerization to either (i) prepare well-defined model systems to address fundamental research questions with regard to the sensit ...

EPFL2020

Limestone calcined clay cements (LC3): raw material processing, sulfate balance and hydration kinetics

Franco Alberto Zunino Sommariva

Limestone calcined clay cements (LC3) are blended cements that combine clinker, limestone, calcined clay and gypsum. The availability of the materials required to produce LC3 and the good performance that it achieves, makes LC3 suitable as a sustainable re ...

EPFL2020

Reactions of nitrogen-containing compounds with ozone: kinetics and mechanisms

Sung Eun Lim

Nitrogen-containing moieties are widespread in natural waters in dissolved organic nitrogen and micropollu-tants. They are often susceptible to an electrophilic attack of ozone because of the electron-rich nature of the neutral form of nitrogen in organic ...

EPFL2020

Reactions of pyrrole, imidazole, and pyrazole with ozone: kinetics and mechanisms

Urs von Gunten, Peter Rudolf Tentscher, Sung Eun Lim

Five-membered nitrogen-containing heterocyclic compounds (azoles) belong to potential moieties in complex structures where transformations during ozonation can occur. This study focused on the azole-ozone chemistry of pyrrole, imidazole, and pyrazole as mo ...

ROYAL SOC CHEMISTRY2020