Remote System for Monitoring Animal Models With Single-Metabolite Bio-Nano-Sensors

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Social Defeat as an Animal Model for Depression

Fiona Hollis

Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human dise ...

Oxford Univ Press2014

lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites

Vassily Hatzimanikatis, Meriç Ataman

In the post-genomic era, Genome-scale metabolic networks (GEMs) have emerged as invaluable tools to understand metabolic capabilities of organisms. Different parts of these metabolic networks are defined as subsystems/pathways, which are sets of functional ...

2017

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

John McKinney, Stewart Cole, Neeraj Dhar, Claudia Sala, Ruben Hartkoorn, Raphael Christopher Sommer, Anthony Vocat, Andréanne Lupien

VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a VCC234718-resistant mutant identified a Y487C substitution in the inosine mo ...

Amer Chemical Soc2017

Robustness Analysis of Controllable-Polarity Silicon Nanowire Devices and Circuits

Hassan Ghasemzadeh Mohammadi

Substantial downscaling of the feature size in current CMOS technology has confronted digital designers with serious challenges including short channel effect and high amount of leakage power. To address these problems, emerging nano-devices, e.g., Silicon ...

EPFL2016

New optical tools for non-invasive imaging and quantification of glucose and nicotinamide riboside in living cells and animals

Aleksandra Konovalova

Glucose is one of the most important metabolites that plays a key role in living organisms, as it is the primary energy source. Glucose metabolism is also an integral part in the pathogenesis of diabetes and cancer. Despite this tremendous impact of glucos ...

EPFL2016

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Marco Bonizzato, Janine Beauparlant, Eduardo Martin Moraud, Pavel Musienko, David Allenson Borton

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Léonie Asboth, Jérôme Gandar, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Julie Kreider, Laetitia Danielle Philippine Baud, Jocelyne Bloch

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Implant-based three-dimensional superimposition of the growing mandible in a rabbit model

The reliable assessment of craniofacial morphological changes during growth requires invariant regions for image registration. As these regions have not yet been identified in three dimensions, intra-osseous implants are required as fiducial markers for th ...

Oxford Univ Press2016

Molecular beam epitaxy of InAs nanowires in SiO2 nanotube templates: challenges and prospects for integration of III-Vs on Si

Anna Fontcuberta i Morral, Jean-Baptiste Leran, Federico Matteini, Frank Meyer, Ruben Ricca, Jelena Vukajlovic Plestina, Heidi Andrea Potts

Guided growth of semiconductor nanowires in nanotube templates has been considered as a potential platform for reproducible integration of III-Vs on silicon or other mismatched substrates. Herein, we report on the challenges and prospects of molecular beam ...

Institute of Physics2016