Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation

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Background In factor XI (FXI) deficiency, bleeding cannot be predicted by routine analyses. Since FXI is involved in tissue factor (TF)-independent propagation loop of coagulation, we hypothesized that investigating the spatiotemporal separated phases of c ...

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Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation

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