Impairment of synaptic plasticity in the primary somatosensory cortex in a model of diabetic mice

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We investigate the mid-infrared chiroptical response of plasmonic nanostructures based on Al-doped ZnO and layers of an aqueous solution of Ladarixin, a chiral pharmaceutical currently under clinical trial for the treatment of type 1 diabetes. We explore t ...

Objectives: The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte-DM association is ...

Accurate segmentation of anatomical substructures within 3D curvilinear structures in medical imaging remains challenging due to their complex geometry and the scarcity of diverse, large-scale datasets for algorithm development and evaluation. In this pape ...

We present the experimental campaigns – namely, three per facility – carried out between 2018 and 2021 in the AKR–2 and CROCUS zero power reactors within the framework of the Horizon 2020 European project CORTEX. Their purpose was to produce high-quality a ...

Introduction: The preservation of the human self—a fundamental yet underexplored aspect of neurosurgical practice—has gained increasing attention in recent years. Research question: How can neural correlates of self-consciousness be identified, monitored, ...

Autophagy is an essential quality control mechanism for maintaining organellar functions in eukaryotic cells. Defective autophagy in pancreatic beta cells has been shown to be involved in the progression of diabetes through impaired insulin secretion under ...

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

Empirical evidence shows that memories that are frequently revisited are easy to recall, and that familiar items involve larger hippocampal representations than less familiar ones. In line with these observations, here we develop a modelling approach to pr ...

How the neocortex modulates hindbrain and spinal circuits is of fundamental interest for understanding mo-tor control and adaptive behaviors. New work from Yang, Kanodia, and Arber demonstrates that there is an exquisite anatomical organization and functio ...

Short-term synaptic plasticity and modulations of the presynaptic vesicle release rate are key components of many working memory models. At the same time, an increasing number of studies suggests a potential role of astrocytes in modulating higher cognitiv ...

Unraveling the neuronal mechanisms of fear learning might allow neuroscientists to make links between a learned behavior and the underlying plasticity at specific synaptic connections. In fear learning, an innocuous sensory event such as a tone (called the ...

The acquisition and re-acquisition of motor skills is an important aspect of daily life and in the recovery after a stroke. Non-invasive brain stimulation (NIBS) is a technique that is used to improve motor learning and enhance motor recovery in stroke sur ...

Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...

Introduction The WHO estimates that each year 5 million people are left permanently disabled after stroke. Adjuvant treatments to promote the effects of rehabilitation are urgently needed. Cortical excitability and neuroplasticity can be enhanced by non-in ...

Impairment of synaptic plasticity in the primary somatosensory cortex in a model of diabetic mice

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Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs

Leukocyte Count and New-onset Diabetes Mellitus in People with Hiv: a Longitudinal Study

Frenet-Serret Frame-based Decomposition for Part Segmentation of 3D Curvilinear Structures

CORTEX experiments – Part I: Modulation campaigns in AKR-2 & CROCUS for the validation of neutron noise codes

Human self and Neurosurgery: Advances and insights from Geneva

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity

Principles of Network Plasticity in Neocortical Microcircuits

A dynamic attractor network model of memory formation, reinforcement and forgetting

Evaluation of a clinical artificial intelligence companion for therapeutic decision making in type 2 diabetes management: a retrospective analysis

Reaching an understanding of cortico-medullary control of forelimb behaviors

Modulation of working memory duration by synaptic and astrocytic mechanisms

Fear Learning: An Evolving Picture for Plasticity at Synaptic Afferents to the Amygdala

Does one size fit all? - Towards the optimization and personalization of non-invasive brain stimulation paradigms to enhance motor learning

Epigenetic plasticity as a signature for memory allocation

A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of transcranial direct current stimulation to the motor cortex after stroke (NETS): study protocol