Cripto localizes nodal at the limiting membrane of early endosomes

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Related publications (29)

Unraveling the Physiological Role of Capillary Morphogenesis Gene 2 in Health and Disease

Capillary Morphogenesis Gene 2 (CMG2) is a 55kDa single-pass transmembrane protein best described as the main Anthrax Toxin Receptor. However, CMG2 physiological role remains elusive and understanding better its in vivo function was the main objective of m ...

EPFL2015

Self-heating hydrogel for mechanically-controlled drug release

Mohamadreza Nassajian Moghadam

Due to our active lifestyle, knee cartilage is at risk for focal defects. Unfortunately, the native healing properties of the articular cartilage are very limited. New strategies to treat cartilage defects are then developed such as the local delivery of g ...

EPFL2015

Interaction of Silver Nanoparticles (AgNP) with Rainbow Trout Gill Cell Lines

Yang Yue

Owing to their unique antimicrobial properties, silver nanoparticles (AgNP) are among the most widely used engineered nanoparticles in a variety of consumer products and medical applications. Their resulting release into the aquatic environment raises conc ...

EPFL2015

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Stéphanie Elisabeth Metzger, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Jeffrey James Rice, Esra Güç, Federico Tortelli

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

American Association for the Advancement of Science2014

Calnexin Controls the STAT3-Mediated Transcriptional Response to EGF

Françoise Gisou van der Goot Grunberg

Calnexin is a well-characterized transnnembrane chaperone involved in the folding of newly synthesized glycoproteins in the lumen of the endoplasmic reticulum (ER). Here, we reveal a previously unrecognized function of calnexin in regulating the transcript ...

Elsevier2013

Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain

Jeffrey Alan Hubbell, Jeffrey James Rice, Federico Tortelli

Tenascin C (TNC) is an extracellular matrix protein that is upregulated during development as well as tissue remodeling. TNC is comprised of multiple independent folding domains, including 15 fibronectin type III-like (TNCIII) domains. The fifth TNCIII dom ...

Public Library of Science2013

Actin filament dynamics impacts keratinocyte stem cell maintenance

Yann Barrandon

Cultured human epidermal keratinocyte stem cells (holoclones) are crucial for regenerative medicine for burns and genetic disorders. In serial culture, holoclones progressively lose their proliferative capacity to become transient amplifying cells with lim ...

Wiley Open Access2013

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

Douglas Hanahan, Anguraj Sadanandam, Krisztian Homicsko, Stephan Wullschleger

Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 ...

Nature Publishing Group2013

Cooperative Roles of SDF-1 alpha and EGF Gradients on Tumor Cell Migration Revealed by a Robust 3D Microfluidic Model

Melody Swartz, Mingming Wu

Chemokine-mediated directed tumor cell migration within a three dimensional (3D) matrix, or chemoinvasion, is an important early step in cancer metastasis. Despite its clinical importance, it is largely unknown how cytokine and growth factor gradients with ...

Public Library of Science2013

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