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The endoplasmic reticulum (ER) forms functional contacts with several cellular organelles and regulates processes such as mitochondrial fission. In a recent issue of Cell, Rowland et al. (2014) extend these findings to endosomes, showing that the ER contacts endosomes at sites containing the WASH subunit FAM21, where it forecasts fission events.
Christian Heinis, Alexander Lund Nielsen, Anne Sofie Luise Zarda, Rebecca Manuela Neeser, Nathan Moïse De Sadeleer
Pierre Gönczy, Graham Knott, Coralie Busso, Mary-Claude Croisier-Coeytaux, Alexander Woglar, Friso Edsger Douma, Gabriela Garcia Rodriguez