Metabolic Messengers: bile acids

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The gut microbiome produces a plethora of metabolites that influence host metabolism. In a recent article published in Cell, Nie and colleagues reveal that 3-succinylated cholic acid, a microbe-derived bile acid, protects against metabolic dysfunction-asso ...

Microbiome metabolism underlies numerous vital ecosystem functions. Individual microbiome members often perform partial catabolism of substrates or do not express all of the metabolic functions required for growth. Microbiome members can complement each ot ...

Introduction Type C hepatic encephalopathy (HE) is a decompensating event of chronic liver disease leading to severe motor and cognitive impairment. The progression of type C HE is associated with changes in brain metabolite concentrations measured by 1H m ...

Nutrition is a key contributor to health. Recently, several studies have identified associations between factors such as microbiota composition and health-related responses to dietary intake, raising the potential of personalized nutritional recommendation ...

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify defici ...

A simple predictive biomarker for fatty liver disease is required for individuals with insulin resistance. Here, we developed a supervised machine learning-based classifier for fatty liver disease using fecal 16S rDNA sequencing data. Based on the Kangbuk ...

The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...

Recently, adaptive non-shivering thermogenesis has attracted considerable attention because it can elevate energy expenditure and help treat obesity. Despite the numerous reports related to UCP1-driven thermogenesis, little is known regarding UCP1-independ ...

Objective The study was undertaken to show the magnitude of interindividual differences in energy expenditure (i.e., heat production) under normal living conditions with the aim of providing physiological evidence to support the advancement of a personaliz ...

All metazoan guts are subject to opposing pressures wherein the immune system must eliminate pathogens while tolerating the presence of symbiotic microbiota. The Imd pathway is an essential defense against invading pathogens in insect guts, but tolerance m ...

Metabolic rate is one of the main parameters affecting the thermal balance of the human body and perception of thermal comfort. Typically, we consider a constant value for a specific type of activity (sitting quiet, standing, etc.) despite the time of the ...

This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models of hepatic encephalopathy (HE). As d ...

Context: Elevating nicotinamide adenine dinucleotide (NAD+) levels systemically improves metabolic health, which can be accomplished via nicotinamide riboside (NR). Previously, it was demonstrated that NR supplementation in high-fat-diet (HFD)-fed mice dec ...

The control of gut homeostasis by autophagy in the context of host-microbiota relationship remains poorly understood. In this issue of Developmental Cell, Nagai et al. (2021) show that autophagy plays a crucial role in enterocytes to prevent the mis-regula ...

Skeletal muscle is one of the most dynamic organs in the human body, which has a vigorous potential to regenerate and adapt to environmental changes. Depending on environments, skeletal muscle enables essential life activities to survive by controlling mov ...

This thesis is composed of four studies centered on investigating cerebral metabolism using magnetic resonance spectroscopy (MRS) of hyperpolarized and non-hyperpolarized compounds at ultra-high field. In the first two chapters, we studied longitudinally t ...

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...

Metabolism is a network of biotransformations that sustain life in cells. Over the past decades, metabolism has been studied in multiple contexts, ranging from medicine to industrial manufacturing. In particular, lipid metabolism has been linked to various ...

Metabolic Messengers: bile acids

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Protecting liver health with microbial-derived succinylated bile acids

A framework for understanding collective microbiome metabolism

Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

Food & You: A digital cohort on personalized nutrition

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells

Interindividual variability of human thermoregulation: Toward personalized ergonomics of the indoor thermal environment

Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria

Dynamics of metabolic rate in male individuals due to the meal and regular office activities

2021 ISHEN guidelines on animal models of hepatic encephalopathy

Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans

Autophagy as a Gatekeeper of Intestinal Homeostasis

Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Mapping and Analysis of the Complexity of Lipid Metabolism for Applications in Health and Sustainability