Publication

Manganese-mediated reductive amidation of esters with nitroarenes

Xile Hu, Chi Wai Cheung, Ning Shen
2019
Journal Articles

Abstract

Amides are ubiquitous molecules in nature and in synthetic chemistry. Here we report a convenient and efficient method to synthesize N-aryl amides via amidation of esters with nitroarenes. In the presence of manganese metal, this amidation proceeded smoothly without the need for additional catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active molecules and intermediates to drug molecules.

Official source

https://infoscience.epfl.ch/entities/publication/3a8547c0-5e3b-4b8d-a3c5-b010c8c0c572

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Manganese-mediated reductive amidation of esters with nitroarenes

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