Publications related to Optimizing light dosimetry in photodynamic therapy of the bronchi by fluorescence spectroscopy

Related publications (19)

Single molecule fluorescence and phosphorescence studies using a scanning tunneling microscope

This thesis investigates novel single-molecule luminescence phenomena at their inherent, sub-molecular length scale. The microscopic understanding of luminescence processes will be crucial for the continued improvement of organic optoelectronic and semicon ...

EPFL2022

Femtosecond X-ray spectroscopy of haem proteins

Majed Chergui, Giulia Fulvia Mancini, Oliviero Cannelli, Dominik Kinschel, Camila Bacellar Cases Da Silveira, Boris Sorokin

We discuss our recently reported femtosecond (fs) X-ray emission spectroscopy results on the ligand dissociation and recombination in nitrosylmyoglobin (MbNO) in the context of previous studies on ferrous haem proteins. We also present a preliminary accoun ...

ROYAL SOC CHEMISTRY2021

Ultrafast X-ray Spectroscopy of Heme Proteins

Dominik Kinschel

With the advent of X-ray free-electron lasers (XFELs) time-resolved X-ray spectroscopic techniques have advanced to the femtosecond regime. These are element selective techniques which offer unique insight into the electronic and chemical environment and d ...

EPFL2020

Ultrafast relaxation of photoexcited superfluid He nanodroplets

Alberto Hernando de Castro, Marcel Drabbels

The relaxation of photoexcited nanosystems is a fundamental process of light–matter interaction. Depending on the couplings of the internal degrees of freedom, relaxation can be ultrafast, converting electronic energy in a few fs, or slow, if the energy is ...

Nature Research2020

Effects of Ozone on the Photochemical and Photophysical Properties of Dissolved Organic Matter

Urs von Gunten, Frank Jonathan Leresche

This study focused on the effects of ozonation on the photochemical and photophysical properties of dissolved organic matter (DOM). Upon ozonation, a decrease in DOM absorbance was observed in parallel with an increase in singlet oxygen (O-1(2)) and fluore ...

AMER CHEMICAL SOC2019

Energy and Charge Transfer Cascade in Methylammonium Lead Bromide Perovskite Nanoparticle Aggregates

Jacques-Edouard Moser, Joël Teuscher, Andrés Burgos Caminal, Marine Eva Fedora Bouduban

Highly photoluminescent hybrid lead halide perovskite nanoparticles have recently attracted a wide interest in the context of high-stake applications, such as light emitting diodes (LEDs), light emitting transistors and lasers. In addition, they constitute ...

Royal Soc Chemistry2017

Measurement of pO2 by luminescence lifetime spectroscopy: A comparative study of the phototoxicity and sensitivity of [Ru(Phen)3]2+ and PdTCPP in vivo

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

Dysfunctions in tissue metabolism can be detected at early stages by oxygen partial pressure (pO(2)) measurement. The measurement of emission lifetimes offers very promising and non-invasive approach to estimate pO(2) in vivo. This study compares two exten ...

Wiley-V C H Verlag Gmbh2016

The use of solid-phase fluorescence spectroscopy in the characterisation of organic matter transformations

Remy Jean Henry Albrecht

Given its high sensitivity and non-destructive nature, fluorescence excitation-emission matrix (EEM) spectroscopy is widely used to differentiate changes and transformations of dissolved or water-extracted organic matter (OM) in natural environments. The s ...

Elsevier2015

Cationic Iridium(III) Complexes with Two Carbene-Based Cyclometalating Ligands: Cis Versus Trans Isomers

Michael Graetzel, Mohammad Khaja Nazeeruddin, Rosario Scopelliti

A series of cationic iridium(III) complexes with two carbene-based cyclometalating ligands and five different NN bipyridine and 1,10-phenanthroline ancillary ligands is presented. For the first time in the frame of a rarely studied class of bis(heterole ...

Amer Chemical Soc2015

Method for nuclear magnetic resonance (NMR) spectroscopy measurements using long-lived coherences (LLC)

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

A method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprises preparation of the sample and carrying out an NMR spectroscopy measurement. Preparation includes excitation of long lived coherences (LLC) between the singlet state S0 and the ...

2013

Novel Concepts for Functional High Resolution Microscopy

Matthias Geissbühler

Functional imaging of biological cells and organs is one of the key techniques that drives new discoveries in life science research and medicine. In this thesis novel concepts for functional imaging at high spatial and temporal resolution are presented. In ...

EPFL2011

Fluorescence Sensors for Lithium Ions and Small Peptides

Kay Severin, Sébastien Rochat

Simple but powerful chemosensors were developed by taking advantage of self-assembly processes. First, we will describe a turn-on fluorescent sensor for the pharmacologically important lithium ion. The sensor can be used in purely aqueous solution, and it ...

Schweizerische Chemische Gesellschaft2010

Plasmon enhanced luminescence from fullerene molecules excited by local electron tunneling

Wolf-Dieter Schneider, François Patthey, Marina Pivetta

Tunneling electrons from a scanning tunneling microscope (STM) induce luminescence from C-60 and C-70 molecules forming fullerene nanocrystals grown on ultrathin NaCl films on Au(111). Intramolecular. uorescence and phosphorescence associated with the tran ...

2009

Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach

Hubert van den Bergh

Photodynamic therapy (PDT) of superficial bladder cancer may cause damages to the normal surrounding bladder wall. Prevention of these is important for bladder healing. We studied the influence of photosensitizer concentration, irradiation parameters, and ...

Wiley-Blackwell2007

SAXES, a high resolution spectrometer for resonant x-ray emission in the 400-1600 eV energy range

Marco Grioni, Thorsten Schmitt, Xiaoqiang Wang

We present a 5 m long spectrometer for soft x rays to be used at a synchrotron radiation beamline for resonant x-ray emission spectroscopy and resonant inelastic x-ray scattering in the 400-1600 eV energy range. It is based on a variable line spacing spher ...

American Institute of Physics2006

Time-Resolved Optical Spectroscopies

Benoît Marie Joseph Deveaud

Spectroscopy basically consists in retrieving information on any system through the use of optical information as a function of wavelength. The examples are countless, and the field is of major importance. For example, the structure of the hydrogen atom ha ...

Elsevier2005

Pharmacokinetics of tetra(m-hydroxyphenyl)chlorin in human plasma and individualized light dosimetry in photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

The pharmacokinetics of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC) was investigated in the plasma of 20 patients by absorption and fluorescence spectroscopy. The temporal behavior was characterized by a rapid decrease in concn. du ...

1998

Frequency-domain fluorescence lifetime imaging for endoscopic clinical cancer photodetection: Apparatus design and preliminary results

Hubert van den Bergh, Georges Wagnières, André Studzinski

We describe a new fluorescence imaging device for clin. cancer photodetection in hollow organs in which the tumor/normal tissue contrast is derived from the fluorescence lifetime of endogenous or exogenous fluorochromes. This fluorescence lifetime contrast ...

Springer US1997

Measurements by fluorescence microscopy of the time-dependent distribution of meso-tetra-hydroxyphenylchlorin in healthy tissues and chemically induced ''early'' squamous cell carcinoma of the Syrian hamster cheek pouch

Hubert van den Bergh, Georges Wagnières

The influence of the time interval between dye administration and detection by fluorescence microscopy was assessed in "early" squamous cell carcinomas of the cheek pouch mucosa and different healthy tissues of the Syrian hamster. Following intracardiac ...

1996