Publication

Microfluidic impedance spectroscopy flow cytometer: Particle size calibration

Philippe Renaud
2004
Conference Papers

Abstract

This paper presents a microfabricated impedance spectroscopy flow cytometer which permits rapid and easy dielectric characterization of cells as they flow in a microchannel. Both a simple theoretical model and a finite element simulation show that the effects of particle size dominate the entire spectrum. Dielectrophoretic forces are used to focus polystyrene beads along the centerline of the channel and decrease the spread in signal amplitude. Measurements of the beads show that size differences of less than 1 gm diameter can be discriminated.

Official source

https://infoscience.epfl.ch/entities/publication/31fa570f-20de-4895-b54c-64d87704f383

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Philippe Renaud
2004
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/31fa570f-20de-4895-b54c-64d87704f383

About this result

Related concepts (23)

Amplitude modulation

Amplitude modulation (AM) is a modulation technique used in electronic communication, most commonly for transmitting messages with a radio wave. In amplitude modulation, the amplitude (signal strength) of the wave is varied in proportion to that of the message signal, such as an audio signal. This technique contrasts with angle modulation, in which either the frequency of the carrier wave is varied, as in frequency modulation, or its phase, as in phase modulation.

Amplitude-shift keying

Amplitude-shift keying (ASK) is a form of amplitude modulation that represents digital data as variations in the amplitude of a carrier wave. In an ASK system, a symbol, representing one or more bits, is sent by transmitting a fixed-amplitude carrier wave at a fixed frequency for a specific time duration. For example, if each symbol represents a single bit, then the carrier signal could be transmitted at nominal amplitude when the input value is 1, but transmitted at reduced amplitude or not at all when the input value is 0.

Finite element method

The finite element method (FEM) is a popular method for numerically solving differential equations arising in engineering and mathematical modeling. Typical problem areas of interest include the traditional fields of structural analysis, heat transfer, fluid flow, mass transport, and electromagnetic potential. The FEM is a general numerical method for solving partial differential equations in two or three space variables (i.e., some boundary value problems).

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Microfluidic impedance spectroscopy flow cytometer: Particle size calibration

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