Publication

Total Synthesis of the Gastroprotective Substance Ai-77-B and of Analogs

Pierre Vogel
1993
Journal Articles

Abstract

The Diels-Alder adducts 8 of furan to 1-cyanovinyl acetate were converted into (methyl 3-chloro-5-043-chlorobenzoyl)-2,3-dideoxy-alpha-DL-arabino-hexofuranosid )uronic acid ((+/-)-18a) and into (methyl 3-azido-5-0-(3-chlorobenzoyl)-2,3-dideoxy-alpha-DL-ribo-hexofuranosid)ur onic acid ((+/-)-41a). These compounds were condensed to (3S)-3-[(1'S)-1'-amino-3'-methylbutyl]-3,4-dihydro-8-hydroxyisocoumarin hydrochloride ((-)-2); the resulting mixtures of diastereoisomeric amides were transformed and separated to give the gastroprotective substance AI-77-B ((-)-1) and analogues.

Official source

https://infoscience.epfl.ch/entities/publication/313ff9f2-88c6-4da5-8642-63146e2a0982

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Pierre Vogel
1993
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/313ff9f2-88c6-4da5-8642-63146e2a0982

About this result

Related concepts (2)

Mixture model

In statistics, a mixture model is a probabilistic model for representing the presence of subpopulations within an overall population, without requiring that an observed data set should identify the sub-population to which an individual observation belongs. Formally a mixture model corresponds to the mixture distribution that represents the probability distribution of observations in the overall population.

Mixture distribution

In probability and statistics, a mixture distribution is the probability distribution of a random variable that is derived from a collection of other random variables as follows: first, a random variable is selected by chance from the collection according to given probabilities of selection, and then the value of the selected random variable is realized. The underlying random variables may be random real numbers, or they may be random vectors (each having the same dimension), in which case the mixture distribution is a multivariate distribution.