Publication

Iron-Catalyzed Mizoroki–Heck Cross-Coupling Reaction with Styrenes

Pierre Vogel
2008
Journal Articles

Abstract

In the presence of iron(II) chloride (FeCl2 ; 20 mol%) and potassium tert-butoxide (t- BuOK; 4 equiv.) in dimethyl sulfoxide (DMSO), aryl and heteroaryl iodides undergo stereoselective Mizoroki–Heck C—C cross-coupling reactions with styrenes at 60 8C giving the corresponding (E)-alkenes. The best yields are obtained upon adding a ligand (80 mol%) such as proline or picolinic acid. Aryl bromides and pyridinyl bromides are also coupled with styrenes but in lower yields.

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Iron-Catalyzed Mizoroki–Heck Cross-Coupling Reaction with Styrenes

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