Publication

Flexprint substrate enzyme sensor for determination of daily glucose-profiles for diabetic patients

Nico de Rooij
2011
Posters

Abstract

The goal is to develop a miniaturized system allowing continuous measurement of glucose concentration profiles over 24 hours for several days. The unique feature of the PharmaSens / IMT approach lies in the insertion mechanism and the needle size to assure optimum user-friendliness and patient comfort. The measurement method is based on classical amperometric detection using an enzymatic membrane. The sensor substrate is made on a flexprint substrate and consists of a 3-electrode cell on a needle-shaped tip of ~100 μm width and is covered with polymeric membranes. The sensor is integrated in a device that combines the insertion mechanism and electronics.

Official source

https://infoscience.epfl.ch/entities/publication/2a464e79-336c-48c3-85be-7cf8b2c82156

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Nico de Rooij
2011
Posters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/2a464e79-336c-48c3-85be-7cf8b2c82156

About this result

Related concepts (32)

Insulin

Insulin (ˈɪn.sjʊ.lɪn, from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the INS gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both.

Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures.

Synthetic membrane

An artificial membrane, or synthetic membrane, is a synthetically created membrane which is usually intended for separation purposes in laboratory or in industry. Synthetic membranes have been successfully used for small and large-scale industrial processes since the middle of twentieth century. A wide variety of synthetic membranes is known. They can be produced from organic materials such as polymers and liquids, as well as inorganic materials. The most of commercially utilized synthetic membranes in separation industry are made of polymeric structures.

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Flexprint substrate enzyme sensor for determination of daily glucose-profiles for diabetic patients

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