Shifting Fitness Landscapes In Response To Altered Environments

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Type I CRISPR-Cas systems typically rely on a two-step process to degrade DNA. First, an RNA-guided complex named Cascade identifies the complementary DNA target. The helicase-nuclease fusion enzyme Cas3 is then recruited in trans for processive DNA degrad ...

Food consumption is among the activities with the most significant environmental impacts, and furthermore contributes to rising health costs. We explored the factors that foster or hinder healthy and sustainable eating in Switzerland. Based on an online ho ...

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria are ...

H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development, and mutations in HMX1 are linked to an ocular defect termed oculoauricular syndrome of Schorderet-Munier-Franceschetti (OAS) (MIM #612109). Recently, additional altered oro ...

In large lakes subject to the Coriolis force, basin-scale gyres and mesoscale eddies, i.e. rotating coherent water masses, play a key role in spreading biochemical materials and energy throughout the lake. In order to assess the spatial and temporal extent ...

Despite the structural and functional information contained in the statistical coupling between pairs of residues in a protein, coevolution associated with function is often obscured by artifactual signals such as genetic drift, which shapes a protein's ph ...

AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...

Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifi ...

Retaining structures above groundwater level support soils that are usually in a state of partial saturation and subject to the actions of atmospheric agents. The current design approach considers the possible extremes of soil conditions - either totally d ...

Shifting Fitness Landscapes In Response To Altered Environments

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Regulation of sedimentation rate shapes the evolution of multicellularity in a close unicellular relative of animals

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

Drivers and Barriers Toward Healthy and Environmentally Sustainable Eating in Switzerland: Linking Impacts to Intentions and Practices

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Premature Vertebral Mineralization in hmx1-Mutant Zebrafish

Basin-scale gyres and mesoscale eddies in large lakes: A novel procedure for their detection and characterization, assessed in Lake Geneva

Extracting phylogenetic dimensions of coevolution reveals hidden functional signals

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

Life cycle environmental assessment of retaining walls in unsaturated soils