Publication

Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

Henry Markram, Kamila Markram, Tania Rinaldi, Jean-Vincent Le Bé
2009
Journal Articles

Abstract

A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperconnectivity of glutamatergic synapses and hyperplastic due to over-expression of NMDA receptors. These changes were restricted to the dimensions of a minicolumn (

Official source

https://infoscience.epfl.ch/entities/publication/28c5e984-c742-472d-bbdb-3281d99610d1

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Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

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