Role of the FoxO3a Transcription Factor in alpha-synuclein Induced Neurodegeneration

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This spreading of prion proteins is at the basis of brain neurodegeneration. This paper deals with the numerical modelling of the misfolding process of a-synuclein in Parkinson's disease. We introduce and analyse a discontinuous Galerkin method for the sem ...

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Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...

Role of the FoxO3a Transcription Factor in alpha-synuclein Induced Neurodegeneration

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The role of the NF-kappaB pathway in Amyotrophic lateral sclerosis pathogenesis

Phantom Boarder Relates to Experimentally‐Induced Presence Hallucinations in Parkinson's Disease

GABAergic-like dopamine synapses in the brain

Detecting the metabolism of individual yeast mutant strain cells when aged, stressed or treated with antioxidants with diamond magnetometry

Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

Longitudinal evaluation of the mechanisms supporting post-stroke motor recovery using TMS-EEG coupling

Discontinuous Galerkin methods for Fisher-Kolmogorov equation with application to a-synuclein spreading in Parkinson's disease

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Effective Inhibition of TDP-43 Aggregation by Native State Stabilization

Bioaccumulation and molecular effects of carbamazepine and methylmercury co-exposure in males of Dreissena polymorpha

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease