Publications related to Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior

Related publications (46)

Deciphering tensile fatigue behavior of UHPFRC using magnetoscopy, DIC and acoustic emission

Eugen Brühwiler, Alain Nussbaumer, Jian Zhan

To explore the governing mechanism underlying the tensile fatigue behavior of Ultra-high Performance Fiber Reinforced Cementitious Composites (UHPFRC), this study tested eight specimens using four advanced non-destructive measurement techniques. First, mag ...

2025

Fluid Chemistry Effect on Localized and Ductile Deformation of a Porous Sandstone

Marie Estelle Solange Violay, Gabriel Gérard Dominique Meyer, Francesco Lazari

In geological reservoirs, pore fluid chemistry can affect rock strength by inducing mineral dissolution, precipitation, and alteration, among other processes. Increasing pressure and temperature can shift deformation from localized to ductile, decreasing p ...

2025

Highly Self-Adhesive and Biodegradable Silk Bioelectronics for All-In-One Imperceptible Long-Term Electrophysiological Biosignals Monitoring

Ata Jedari Golparvar

Skin-like bioelectronics offer a transformative technological frontier, catering to continuous and real-time yet highly imperceptible and socially discreet digital healthcare. The key technological breakthrough enabling these innovations stems from advance ...

2025

The Regulation of Transcription Factors Binding Site Occupancies by Their Concentrations

Romane Joséphine Madeleine Mizeret

The precise control of transcription factor (TF) concentrations is crucial for While TF concentration gradients are well-characterized in model organisms like Drosophila and Caenorhabditis elegans, their quantitative relationship with genomic occupancy in ...

EPFL2025

An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells

Dominique Pioletti

Articular cartilage focal lesion remains an intractable challenge in sports medicine, and autologous chondrocytes' implantation (ACI) is one of the most commonly utilized treatment modality for this ailment. However, the current ACI technique requires two ...

AMER CHEMICAL SOC2021

Wireless soft microscale actuators and robotic devices to study mechanobiology

Raquel Filipa Penacho Parreira

Tissues morphogenesis and homeostasis involve the spatiotemporal regulation of mechanics at multiple scales. Characterization of mechanical properties of biological systems as well as investigating the effects of mechanical forces on biological function ar ...

EPFL2021

Gold nanoparticles as a new tool in amyloid studies

Urszula Beata Cendrowska

The misfolding and self-assembly of proteins into fibrils is a hallmark of several neurodegenerative and systemic diseases. These disease-associated proteins have the propensity to form fibrils with a cross-Î² sheet structure, called amyloids. Amyloids can ...

EPFL2020

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Philipp Bucher, Cathrin Brisken, Giovanna Ambrosini, Rachel Marcone, Céline Berthe Constantin, Dalya Ataca, Marie Shamseddin, Csaba Ferenc László, Marian Caikovski, Patrik Aouad

Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...

Nature Research2020

Tensile Properties of Ex-Situ Ti-TiC Metal Matrix Composites Manufactured by Laser Powder Bed Fusion

Roland Logé

Titanium-based Metal Matrix Composites (MMCs) manufactured by additive manufacturing offer tremendous lightweighting opportunities. However, processing the high reinforcement contents needed to substantially improve elastic modulus while conserving signifi ...

2024

Mechanical properties and cytocompatibility of dense and porous Zn produced by laser powder bed fusion for biodegradable implant applications

Andreas Mortensen, Ludger Weber

In this work, the macrotexture of dense Zn produced by laser powder bed fusion (LPBF) was studied and the mechanical properties for different tensile bar orientations were measured. The compressive strength of LPBF Zn scaffolds with five different unit cel ...

ELSEVIER SCI LTD2020

ERK signalling eliminates Nanog and maintains Oct4 to drive the formative pluripotency transition

David Michael Suter

Naïve epiblast cells in the embryo and pluripotent stem cells in vitro undergo developmental progression to a formative state competent for lineage specification. During this transition, transcription factors and chromatin are rewired to encode new functio ...

2024

Adamts18 Function in Mammary Gland Development

Dalya Ataca

Ovarian hormones control mammary gland development and impinge on breast carcinogenesis acting via their cognate receptors in the luminal epithelium. The extracellular matrix has a key role in physiology and disease but how the two are linked is poorly und ...

EPFL2019

Improved Material Formulations for Thick Adhesive Joints in Wind Turbine Blades

Jialiang Fan

Wind turbine rotor blades are usually fabricated using composite materials and epoxy adhesive to bond the elements together. Due to their large size, the thickness of the adhesive layer varies from 1 to up to 30 mm depending on the position. The failure of ...

EPFL2024

Understanding semiconductor nanostructures via advanced electron microscopy and spectroscopy

Reza Zamani

Transmission electron microscopy (TEM) offers an ample range of complementary techniques which are able to provide essential information about the physical, chemical and structural properties of materials at the atomic scale, and hence makes a vast impact ...

IOP PUBLISHING LTD2019

Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice

Matthias Lütolf, Saba Rezakhani, Antonius Chrisnandy

Glandular epithelia, including mammary gland (MG) and prostate, are composed of luminal and basal cells. During embryonic development, glandular epithelia arise from multipotent stem cells (SCs) that are replaced after birth by unipotent basal and unipoten ...

Nature Research2024

Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications

Pierre-Arnaud Aeberhard, Dominique Pioletti, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Jens Antons, Anthony Grognuz

Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could addi ...

2020

The rise of aerial additive manufacturing in construction: a review of material advancements

Mirko Kovac, Yusuf Furkan Kaya

The construction industry has recently increased the adoption of additive manufacturing (AM, also known as 3D-printing) technologies. This review paper presents the state of the art of ground-based AM systems in construction, focusing comprehensively on de ...

2024

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

Giovanni Sorrentino

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholi ...

Springer2019

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Francesco Stellacci, Evangelia-Nefeli Athanasopoulou

Collagen-rich tissues in the cornea exhibit unique and highly organized extracellular matrix ultrastructures, which contribute to its high load-bearing capacity and light transmittance. Corneal collagen fibrils are controlled during development by small le ...

WILEY-V C H VERLAG GMBH2018

Inducible CXCL12/CXCR4–dependent extramedullary hematopoietic niches in the adrenal gland

Jessica Sordet, Aurélien Laurent Jean-Charles Oggier

Adult hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) hematopoietic niche, which regulates HSPC quiescence, self-renewal, and commitment in a demand-adapted manner. Although the complex BM niche is responsible for adult hemat ...

2024