Publication

Bioprocess monitoring and control using the combination of fluorescence, mid-IR, and Raman spectroscopy

Urs von Stockar, Sergio Valentinotti, Christopher Cannizzaro, Martin Rhiel
2001
Conference Papers

Abstract

Spectroscopic monitoring techniques have many advantages for bioprocess monitoring and control, including simultaneous multi-analyte detns., in-situ sterilizability, and low maintenance during operation. This study discusses the combined application of fluorescence, mid-IR, and Raman spectroscopic techniques for a comprehensive monitoring of Phaffia rhodozyma yeast cultures during batch and fed-batch operation for the prodn. of astaxanthin, a carotenoid of industrial importance. Reliability of the different techniques will be detailed along with their utility to control the growth rate at an optimum value. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/23df1680-a740-456e-862b-c66204049b68

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Urs von Stockar, Sergio Valentinotti, Christopher Cannizzaro, Martin Rhiel
2001
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/23df1680-a740-456e-862b-c66204049b68

About this result

Related concepts (16)

Raman spectroscopy

Raman spectroscopy (ˈrɑːmən) (named after Indian physicist C. V. Raman) is a spectroscopic technique typically used to determine vibrational modes of molecules, although rotational and other low-frequency modes of systems may also be observed. Raman spectroscopy is commonly used in chemistry to provide a structural fingerprint by which molecules can be identified. Raman spectroscopy relies upon inelastic scattering of photons, known as Raman scattering.

Spectroscopy

Spectroscopy is the field of study that measures and interprets the electromagnetic spectra that result from the interaction between electromagnetic radiation and matter as a function of the wavelength or frequency of the radiation. Matter waves and acoustic waves can also be considered forms of radiative energy, and recently gravitational waves have been associated with a spectral signature in the context of the Laser Interferometer Gravitational-Wave Observatory (LIGO).

Resonance Raman spectroscopy

Resonance Raman spectroscopy (RR spectroscopy or RRS) is a variant of Raman spectroscopy in which the incident photon energy is close in energy to an electronic transition of a compound or material under examination. This similarity in energy (resonance) leads to greatly increased intensity of the Raman scattering of certain vibrational modes, compared to ordinary Raman spectroscopy. Resonance Raman spectroscopy has much greater sensitivity than non-resonance Raman spectroscopy, allowing for the analysis of compounds with inherently weak Raman scattering intensities, or at very low concentrations.

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Bioprocess monitoring and control using the combination of fluorescence, mid-IR, and Raman spectroscopy

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