Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization

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Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

Arthur César Pinon, David Lyndon Emsley, Aaron James Rossini, Jasmine Viger-Gravel

Here, we show how dynamic nuclear polarization (DNP) NMR spectroscopy experiments permit the atomic level structural characterization of loaded and empty lipid nanoparticles (LNPs). The LNPs used here were synthesized by the microfluidic mixing technique a ...

2018

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser, Céline Samira Wyss, Martin Broome, Peyman Karami

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

2018

Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Jutta Christine Wandrey, Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Luca Szabó

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

American Chemical Society2017

Dopamine induces soluble alpha-synuclein oligomers and nigrostriatal degeneration

Elpida Tsika

Parkinson's disease (PD) is defined by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy body inclusions containing aggregated alpha-synuclein. Efforts to explain dopamine neuron vulnerability are hindered by the lack of do ...

Nature Publishing Group2017

Effect of light and oxygen on repetitive bacterial inactivation on uniform, adhesive, robust and stable Cu-polyester surfaces

Juan Kiwi, César Pulgarin, Rosendo Sanjines, Sami Rtimi

This study reports new findings on the sputtered Cu-polyester (Cu-PES) bacterial inactivation under low intensity visible light (lambda > 400 nm). Cu-PES samples sputtered for 160 s led to the complete inactivation of E. coli in anaerobic and aerobic media ...

De Gruyter Mouton2017

Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes

Rosario Scopelliti, Paul Joseph Dyson, Emilia Paunescu, Mylène Soudani, Lucinda Kate Batchelor

Dinudear metal complexes have emerged as a promising class of anticancer compounds with the ability to cross-link biomolecular targets. Here, we describe two novel series of phosphine-linked dinudear ruthenium(II) p-cyrnene and gold(I) complexes, in which ...

2017

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

Harm-Anton Klok, Maarten Danial, Frederik Roman Wurm

A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...

2017

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