Targeted neurotechnology restores walking in humans with spinal cord injury

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Over the past decade, there has been a growing interest in the development of intelligent neural interface systems-on-chip (SoCs) for a range of neurological disorders and emerging brain-machine interface (BMI) applications. The shift toward creating intel ...

Integrating smart algorithms on neural devices presents significant opportunities for various brain disorders. In this paper, we review the latest advancements in the development of three categories of intelligent neural prostheses featuring embedded signa ...

Spinal Cord Injury (SCI) affects almost 500,000 people every year, causing complete paralysis of both legs in severe cases, with no current treatment perspective. However, new neuroengineering technologies, such as the Brain Spine Interface (BSI), have eme ...

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

Over the past two decades, epidural electrical stimulation (EES) has transitioned from a treatment for chronic pain to a promising paradigm for ameliorating deficits associated with neurological disorders like spinal cord injury (SCI) and Parkinson's Disea ...

In the last decades, clinical neuroscience found a novel ally in neurotechnologies, devices able to record and stimulate electrical activity in the nervous system. These technologies improved the ability to diagnose and treat neural disorders. Neurotechnol ...

Background Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse spinal cord lesions remains less under ...

Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or ...

Neurotechnology includes artificial devices integrated with the neural tissue to mitigate the burden of neurological and mental disorders. This field has significantly expanded its range of applications thanks to the development of flexible, stretchable an ...

Peripheral neural interfaces have been successfully used in the recent past to restore sensory-motor functions in disabled subjects and for the neuromodulation of the autonomic nervous system. The optimization of these neural interfaces is crucial for ethi ...

Neurological disorders have a strong negative impact on the quality of life of affected patients, their close relatives as well as on the health economic system. Early diagnosis associated with better treatment outcomes remain difficult to reach. Similarly ...

Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simulta ...

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

The delivery of molecules and genes to the central nervous system (CNS) poses a major challenge for the treatment of neurodegenerative diseases. CNS disorders require long-term intervention and the presence of the blood-brain barrier (BBB) restricts the pe ...

Targeted neurotechnology restores walking in humans with spinal cord injury

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Intelligent Neural Interfaces: An Emerging Era in Neurotechnology

Intelligent Neural Interfaces: An Emerging Era in Neurotechnology

Brain-controlled spinal cord stimulation to restore mobility after spinal cord injury

Walking naturally after spinal cord injury using a brain-spine interface

Closed-Loop Control of Epidural Electrical Stimulation in Patients with Spinal Cord Injury and Parkinson's Disease

Clinical neuroscience and neurotechnology: An amazing symbiosis

Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis

Enhancing analgesic spinal cord stimulation for chronic pain with personalized immersive virtual reality

Transient electronics: new opportunities for implantable neurotechnology

Tutorial: a computational framework for the design and optimization of peripheral neural interfaces

Brain-computer interfaces based on intracortical recordings of neural activity for restoration of movement and communication of people with paralysis

A Microfluidic Brain Interface for In Vivo Recording of Neurochemical Activity

A Wireless System with Stimulation and Recording Capabilities for Interfacing Peripheral Nerves in Rodents

Neuroprosthetic rehabilitation and use-dependent plasticity following severe spinal cord injury

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

Adeno-Associated Virus-Mediated Gene Delivery for the Treatment of Amyotrophic Lateral Sclerosis and other Motor Neuron Disorders