Diffusion behavior of cerebral metabolites of congenital portal systemic shunt mice assessed noninvasively by diffusion-weighted H-1 magnetic resonance spectroscopy

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Challenges for biophysical modeling of microstructure

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25 years. In this review, we dwell on the various challenges along the journey of bringing a biophysical model from initial design to clinical implementation, identifyi ...

2020

Apparent diffusion coefficient measured by diffusion MRI of moving and deforming domains

Jan Sickmann Hesthaven

The modeling of the diffusion MRI signal from moving and deforming organs such as the heart is challenging due to significant motion and deformation of the imaged medium during the signal acquisition. Recently, a mathematical formulation of the Bloch-Torre ...

Academic Press Inc - Elsevier Science2020

Exploring dynamic functional connectivity by incorporating prior knowledge of brain structure

Anjali Bagunu Tarun

The synchronized firing of distant neuronal populations gives rise to a wide array of functional brain networks that underlie human brain function. Given the enormous perception, learning, and cognition potential of the human brain, it is not surprising th ...

EPFL2020

Thermal coarsening of individual titanate nanowires and their assemblies: Surface vs. bulk diffusion

Luca Rossi, László Forró, Xavier Berdat, Massimo Spina, Endre Horvath, Laurent Syavoch Bernard, Sergiy Katrych

The thermal coarsening of titanate nanowires was investigated from room temperature to 1000 degrees C by AFM, SEM, XRD and Raman spectroscopy. Phase transformation kinetics and the external morphology were studied in two configurations: i) as individual an ...

2020

Nano-imaging trace elements at organelle levels in substantia nigra overexpressing alpha-synuclein to model Parkinson's disease

Philippe Colin, Bernard Schneider, Graham Knott

Sub-cellular trace element quantifications of nano-heterogeneities in brain tissues offer unprecedented ways to explore at elemental level the interplay between cellular compartments in neurodegenerative pathologies. We designed a quasi-correlative method ...

NATURE PUBLISHING GROUP2020

Oxygen diffusion through air–water free surfaces in a pump–turbine operating in condenser mode

François Avellan, Elena Vagnoni, Loïc Andolfatto, Pierre Leroy

The present research aims at understanding the mass transfer of air into water in a reversible pump turbine operating in condenser mode. In particular, the diffusion of oxygen through the water free-surface both in the vaneless gap between the impeller bla ...

2019

Particle-Based Simulation Reveals Macromolecular Crowding Effects on the Michaelis-Menten Mechanism

Vassily Hatzimanikatis, Daniel Robert Weilandt

Many computational models for analyzing and predicting cell physiology rely on in vitro data collected in dilute and controlled buffer solutions. However, this can mislead models because up to 40% of the intracellular volume-depending on the organism, the ...

2019

In vivo diffusion magnetic resonance imaging of the white matter microstructure from dictionaries generated by Monte Carlo simulations: development and validation

Gaëtan Olivier D Rensonnet

Non-invasive virtual histology of white matter tissues is the ultimate promise of diffusion-weighted MRI (DW-MRI). This hope is fueled by the exquisite sensitivity of DW-MRI to micrometer-scale displacement of diffusing water molecules, averaged over a who ...

EPFL2019

Truncated Levy motion through path integrals and applications to nondiffusive suprathermal ion transport

Ambrogio Fasoli, Ivo Furno, Paolo Ricci, Oulfa Chellaï, Marcelo Baquero Ruiz, Fabian Manke

Fractional Levy motion has been derived from its generalized Langevin equation via path integrals in earlier works and has since proven to be a useful model for nonlocal and non-Markovian processes, especially in the context of nondiffusive transport. Here ...

AMER PHYSICAL SOC2019

Metabolic implications of organelle-mitochondria communication

Carlos Canto Alvarez

Cellular organelles are not static but show dynamism-a property that is likely relevant for their function. In addition, they interact with other organelles in a highly dynamic manner. In this review, we analyze the proteins involved in the interaction bet ...

WILEY2019

Dissolution-reprecipitation reaction of dolomite: investigation of self- and tracer-diffusion using SIMS mini-spot and NanoSIMS profiles

Lukas Baumgartner, Anders Meibom, Stéphane Laurent Escrig

Recrystallization of minerals due to fluid infiltration modifies their original chemical and isotopic signature. Such processes are sought after as they give access to timescales of geologic processes, which are commonly quantified using diffusion chronome ...

2019

Combined Nuclear Magnetic Resonance and Molecular Dynamics Study of Methane Adsorption in M-2(dobdc) Metal-Organic Frameworks

Berend Smit, Efrem Daniel Braun, Rocio Mercado, Amber Kashan Mace

We examine the diffusion of methane in the metal organic frameworks M-2(dobdc) (M = Mg, Ni, Zn; dobdc(4-) = 2,5-diwddo-1,4-benzenedicarboxylate) as a function of methane loading through a combination of nuclear magnetic resonance and molecular dynamics sim ...

2019

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