Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

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Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously show ...

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The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

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Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin -stimulated sarcolemmal and endosomal GLUT4 translocation

Competitive Neural Layer-based Method to Identify People with High Risk for Diabetic Foot

Heart Rate Variability Triangular Index as a Predictor of Cardiovascular Mortality in Patients With Atrial Fibrillation

Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer's disease

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma

Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS

Dynamics of brain function in preterm-born young adolescents

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model

Cross-species functional modules link proteostasis to human normal aging