Statistical Analysis of Protein Sequences: A Coevolutionary Study of Molecular Chaperones

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The first observation of the

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decay and the most precise measurement of the branching fraction of the ${{{\varLambda } ^0_{b}} !\rightarrow ...

Scarless genome editing in budding yeast with elimination of the selection marker has many advantages. Some markers such as URA3 and TRP1 can be recycled through counterselection. This permits seamless genome modification with pop-in/pop-out, in which a DN ...

G protein-coupled receptors (GPCRs) are the largest human membrane protein family that transduce extracellular signals into cellular responses. They are major pharmacological targets, with approximately 26% of marketed drugs targeting GPCRs, primarily at t ...

Microsecond time-resolved cryo-electron microscopy has emerged as a novel approach for directly observing protein dynamics. By providing microsecond temporal and near-atomic spatial resolution, it has the potential to elucidate a wide range of dynamics tha ...

As the fundamental machinery orchestrating cellular functions, proteins influence the state of every cell profoundly. As cells exhibit significant variations from one to another, analyzing the proteome on a single-cell level is imperative to unravel their ...

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Analysis of single-cell datasets generated from diverse organisms offers unprecedented opportunities to unravel fundamental evolutionary processes of conservation and diversification of cell types. However, interspecies genomic differences limit the joint ...

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Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

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In the domain of computational structural biology, predicting protein interactions based on molecular structure remains a pivotal challenge. This thesis delves into this challenge through a series of interconnected studies. The first chapter introduces th ...

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G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compounds and therapeutic drugs. While most of these ligands bind to their target GPCR with high affinity, selectivity is often l ...

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Statistical Analysis of Protein Sequences: A Coevolutionary Study of Molecular Chaperones

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Multimodal Prediction Framework for Total Shoulder Arthroplasty Outcomes: Integrating Morphological, Musculoskeletal, Finite Element, and Bayesian Causal Models

Observation of the ${{{\varLambda } ^0_{b}} \!\rightarrow {{J \hspace{-1.66656pt}/\hspace{-1.111pt}\psi }} {{\varXi } ^-} {{K} ^+} }$ and ${{{{\varXi } ^0_{b}} \!\rightarrow {{J \hspace{-1.66656pt}/\hspace{-1.111pt}\psi }} {{\varXi } ^-} {{\pi } ^+} }}$ decays

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